diff --git a/pkgs/by-name/bl/ble-serial/package.nix b/pkgs/by-name/bl/ble-serial/package.nix
new file mode 100644
index 000000000000..0cfcce951911
--- /dev/null
+++ b/pkgs/by-name/bl/ble-serial/package.nix
@@ -0,0 +1 @@
+{ python3Packages }: with python3Packages; toPythonApplication ble-serial
diff --git a/pkgs/by-name/li/libopaque/package.nix b/pkgs/by-name/li/libopaque/package.nix
index 81ee5e4174c9..f348997dd8d3 100644
--- a/pkgs/by-name/li/libopaque/package.nix
+++ b/pkgs/by-name/li/libopaque/package.nix
@@ -28,6 +28,13 @@ stdenv.mkDerivation (finalAttrs: {
     liboprf
   ];
 
+  # expand_message_xmd has been renamed to oprf_expand_message_xmd in liboprf
+  # TODO: remove in the next release
+  postPatch = ''
+    substituteInPlace opaque.c \
+      --replace-fail 'expand_message_xmd' 'oprf_expand_message_xmd'
+  '';
+
   postInstall = ''
     mkdir -p ${placeholder "out"}/lib/pkgconfig
     cp ../libopaque.pc ${placeholder "out"}/lib/pkgconfig/
diff --git a/pkgs/by-name/li/liboprf/package.nix b/pkgs/by-name/li/liboprf/package.nix
index 15a453da8eca..c936a121b585 100644
--- a/pkgs/by-name/li/liboprf/package.nix
+++ b/pkgs/by-name/li/liboprf/package.nix
@@ -9,13 +9,13 @@
 
 stdenv.mkDerivation (finalAttrs: {
   pname = "liboprf";
-  version = "0.8.0";
+  version = "0.9.2";
 
   src = fetchFromGitHub {
     owner = "stef";
     repo = "liboprf";
     tag = "v${finalAttrs.version}";
-    hash = "sha256-xDE9UkHDAaA7zC6IxxEIUG7ziS1yYNLJbmVJZLJyL7U=";
+    hash = "sha256-Toja0rR0321i7L1dsB9YxrwNJwKUzuSfK5LLR3tex7U=";
   };
 
   sourceRoot = "${finalAttrs.src.name}/src";
diff --git a/pkgs/development/python-modules/ble-serial/default.nix b/pkgs/development/python-modules/ble-serial/default.nix
new file mode 100644
index 000000000000..1e3c7315304d
--- /dev/null
+++ b/pkgs/development/python-modules/ble-serial/default.nix
@@ -0,0 +1,57 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+  hatchling,
+  bleak,
+  coloredlogs,
+  pyserial,
+  bless,
+}:
+
+buildPythonPackage rec {
+  pname = "ble-serial";
+  version = "3.0.0";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "Jakeler";
+    repo = "ble-serial";
+    tag = "v${version}";
+    hash = "sha256-lbqu6VeE8XEIUvUILqKsTA+0/lxTr8GTbUBkSae/ruE=";
+    fetchSubmodules = true;
+  };
+
+  build-system = [
+    hatchling
+  ];
+
+  dependencies = [
+    bleak
+    coloredlogs
+    pyserial
+  ];
+
+  optional-dependencies = {
+    server = [
+      bless
+    ];
+  };
+
+  # Requires real hardware to test
+  # https://github.com/Jakeler/ble-serial/blob/3f1a619208a0eb372a0993aadc086c4842946f21/tests/test.py
+  doCheck = false;
+
+  pythonImportsCheck = [
+    "ble_serial.bluetooth.ble_client"
+    "ble_serial.scan"
+  ];
+
+  meta = {
+    description = "\"RFCOMM for BLE\" a Serial UART over Bluetooth low energy (4+) bridge";
+    homepage = "https://github.com/Jakeler/ble-serial";
+    license = lib.licenses.mit;
+    maintainers = with lib.maintainers; [ eljamm ];
+    platforms = lib.platforms.unix;
+  };
+}
diff --git a/pkgs/development/python-modules/pyoprf/default.nix b/pkgs/development/python-modules/pyoprf/default.nix
index 317533daa588..f7f525034e79 100644
--- a/pkgs/development/python-modules/pyoprf/default.nix
+++ b/pkgs/development/python-modules/pyoprf/default.nix
@@ -4,7 +4,11 @@
   buildPythonPackage,
   liboprf,
   setuptools,
+  ble-serial,
+  pyserial,
+  pyserial-asyncio,
   pysodium,
+  pyudev,
   securestring,
   pytestCheckHook,
 }:
@@ -32,7 +36,11 @@ buildPythonPackage rec {
   build-system = [ setuptools ];
 
   dependencies = [
+    ble-serial
+    pyserial
+    pyserial-asyncio
     pysodium
+    pyudev
     securestring
   ];
 
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index f14f88370935..6d8c838dba4f 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -1971,6 +1971,8 @@ self: super: with self; {
 
   blake3 = callPackage ../development/python-modules/blake3 { };
 
+  ble-serial = callPackage ../development/python-modules/ble-serial { };
+
   bleach = callPackage ../development/python-modules/bleach { };
 
   bleach-allowlist = callPackage ../development/python-modules/bleach-allowlist { };