diff --git a/pkgs/by-name/op/opshin/package.nix b/pkgs/by-name/op/opshin/package.nix
index 73f663a60815..b5c8c8fcce65 100644
--- a/pkgs/by-name/op/opshin/package.nix
+++ b/pkgs/by-name/op/opshin/package.nix
@@ -4,9 +4,20 @@
   python3,
 }:
 
-python3.pkgs.buildPythonApplication rec {
+let
+  python3' = python3.override {
+    self = python3;
+    packageOverrides = (
+      final: prev: {
+        cbor2 = prev.cbor2WithoutCExtensions;
+      }
+    );
+  };
+in
+
+python3'.pkgs.buildPythonApplication rec {
   pname = "opshin";
-  version = "0.24.1";
+  version = "0.24.2";
 
   format = "pyproject";
 
@@ -14,10 +25,10 @@ python3.pkgs.buildPythonApplication rec {
     owner = "OpShin";
     repo = "opshin";
     tag = version;
-    hash = "sha256-+uuTEszA5p/qhvthM3Uje6yX3urbIUAKKfDZ4JXEYYQ=";
+    hash = "sha256-L0vWEXlghXssT9oUw5AYG3/4ALoB/NH90JV8Kdl2n30=";
   };
 
-  propagatedBuildInputs = with python3.pkgs; [
+  propagatedBuildInputs = with python3'.pkgs; [
     setuptools
     poetry-core
     uplc
@@ -28,11 +39,6 @@ python3.pkgs.buildPythonApplication rec {
     ordered-set
   ];
 
-  pythonRelaxDeps = [
-    "pluthon"
-    "uplc"
-  ];
-
   meta = with lib; {
     description = "Simple pythonic programming language for Smart Contracts on Cardano";
     homepage = "https://opshin.dev";
diff --git a/pkgs/development/python-modules/cbor2/default.nix b/pkgs/development/python-modules/cbor2/default.nix
index a3ed8ceea17f..a9fd9152666e 100644
--- a/pkgs/development/python-modules/cbor2/default.nix
+++ b/pkgs/development/python-modules/cbor2/default.nix
@@ -4,6 +4,8 @@
   fetchPypi,
   pythonOlder,
 
+  withCExtensions ? true,
+
   # build-system
   setuptools,
   setuptools-scm,
@@ -39,6 +41,14 @@ buildPythonPackage rec {
     pytestCheckHook
   ];
 
+  env = lib.optionalAttrs (!withCExtensions) {
+    CBOR2_BUILD_C_EXTENSION = "0";
+  };
+
+  passthru = {
+    inherit withCExtensions;
+  };
+
   meta = with lib; {
     changelog = "https://github.com/agronholm/cbor2/releases/tag/${version}";
     description = "Python CBOR (de)serializer with extensive tag support";
diff --git a/pkgs/development/python-modules/pluthon/default.nix b/pkgs/development/python-modules/pluthon/default.nix
index 21994bd0817e..47dd7fad00b0 100644
--- a/pkgs/development/python-modules/pluthon/default.nix
+++ b/pkgs/development/python-modules/pluthon/default.nix
@@ -12,7 +12,7 @@
 
 buildPythonPackage rec {
   pname = "pluthon";
-  version = "1.0.0";
+  version = "1.1.0";
 
   format = "pyproject";
 
@@ -20,7 +20,7 @@ buildPythonPackage rec {
     owner = "OpShin";
     repo = "pluthon";
     rev = version;
-    hash = "sha256-IYpkb/RXRu53HoeVKik7Jog5FyXwrWItrxSla9dN0s4=";
+    hash = "sha256-t8KWm2eBq6CzFPAWN9pgbpF62hvNNZWCpphJsY5T2OQ=";
   };
 
   propagatedBuildInputs = [
diff --git a/pkgs/development/python-modules/pycardano/default.nix b/pkgs/development/python-modules/pycardano/default.nix
index e5f164e9fe92..7b36de98ace2 100644
--- a/pkgs/development/python-modules/pycardano/default.nix
+++ b/pkgs/development/python-modules/pycardano/default.nix
@@ -25,7 +25,7 @@
 }:
 
 let
-  cose_0_9_dev8 = cose.overridePythonAttrs (old: rec {
+  cose_0_9_dev8 = (cose.override { inherit cbor2; }).overridePythonAttrs (old: rec {
     version = "0.9.dev8";
     src = (
       old.src.override {
@@ -38,14 +38,14 @@ let
 in
 buildPythonPackage rec {
   pname = "pycardano";
-  version = "0.12.3";
+  version = "0.14.0";
   pyproject = true;
 
   src = fetchFromGitHub {
     owner = "Python-Cardano";
     repo = "pycardano";
     tag = "v${version}";
-    hash = "sha256-jxgskdQ7Us+utndUgFYK7G2IW/e5QbeXytOsxQfFiJI=";
+    hash = "sha256-W5N254tND7mI0oR82YhMFWn4zVVs3ygYOqXOBMO3sXY=";
   };
 
   build-system = [
@@ -88,5 +88,9 @@ buildPythonPackage rec {
     homepage = "https://github.com/Python-Cardano/pycardano";
     license = lib.licenses.mit;
     maintainers = with lib.maintainers; [ t4ccer ];
+    # https://github.com/Python-Cardano/pycardano/blob/v0.13.2/Makefile#L26-L39
+    # cbor2 with C extensions fail tests due to differences in used sized vs unsized arrays
+    # more info: https://github.com/NixOS/nixpkgs/pull/402433#issuecomment-2916520286
+    broken = cbor2.withCExtensions; # consider overriding cbor2 with cbor2WithoutCExtensions
   };
 }
diff --git a/pkgs/development/python-modules/uplc/default.nix b/pkgs/development/python-modules/uplc/default.nix
index dd8e8cbea634..e9a2874b17c0 100644
--- a/pkgs/development/python-modules/uplc/default.nix
+++ b/pkgs/development/python-modules/uplc/default.nix
@@ -8,14 +8,16 @@
   setuptools,
   poetry-core,
   frozendict,
+  cbor2WithoutCExtensions,
   cbor2,
   rply,
   pycardano,
+  uplc,
 }:
 
 buildPythonPackage rec {
   pname = "uplc";
-  version = "1.0.7";
+  version = "1.0.10";
 
   format = "pyproject";
 
@@ -23,7 +25,7 @@ buildPythonPackage rec {
     owner = "OpShin";
     repo = "uplc";
     tag = version;
-    hash = "sha256-xK2k0XLybWqyP5Qa2Oby8YBgiiswR++yVK7NPgpdSa0=";
+    hash = "sha256-Owo4W4jChrdYnz11BbWQdm2SiwFwOJlqjYutuRyjpxs=";
   };
 
   propagatedBuildInputs = [
@@ -37,8 +39,17 @@ buildPythonPackage rec {
     python-secp256k1-cardano
   ];
 
+  # Support cbor2 without C extensions
+  postPatch = lib.optionalString (!cbor2.withCExtensions) ''
+    substituteInPlace uplc/ast.py --replace-fail 'from _cbor2' 'from cbor2'
+  '';
+
   pythonImportsCheck = [ "uplc" ];
 
+  passthru.tests.withoutCExtensions = uplc.override {
+    cbor2 = cbor2WithoutCExtensions;
+  };
+
   meta = with lib; {
     description = "Python implementation of untyped plutus language core";
     homepage = "https://github.com/OpShin/uplc";
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 0b4dad01e546..c81f03a31d53 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -2300,6 +2300,10 @@ self: super: with self; {
 
   cbor2 = callPackage ../development/python-modules/cbor2 { };
 
+  cbor2WithoutCExtensions = callPackage ../development/python-modules/cbor2 {
+    withCExtensions = false;
+  };
+
   cccolutils = callPackage ../development/python-modules/cccolutils { krb5-c = pkgs.krb5; };
 
   cdcs = callPackage ../development/python-modules/cdcs { };