diff --git a/pkgs/development/python-modules/nidaqmx/default.nix b/pkgs/development/python-modules/nidaqmx/default.nix
index 9d916cc9324d..937688d0c4e3 100644
--- a/pkgs/development/python-modules/nidaqmx/default.nix
+++ b/pkgs/development/python-modules/nidaqmx/default.nix
@@ -7,6 +7,7 @@
 , pykka
 , enum34
 , pythonOlder
+, pythonAtLeast
 }:
 
 # Note we currently do not patch the path to the drivers
@@ -17,6 +18,9 @@ buildPythonPackage rec {
   pname = "nidaqmx";
   version = src.rev;
 
+  # 3.10 is not supported, upstream inactive
+  disabled = pythonAtleast "3.10";
+
   src = fetchFromGitHub {
     owner = "ni";
     repo = "nidaqmx-python";