diff --git a/pkgs/development/python-modules/itkwasm/default.nix b/pkgs/development/python-modules/itkwasm/default.nix
new file mode 100644
index 000000000000..663df3e947b0
--- /dev/null
+++ b/pkgs/development/python-modules/itkwasm/default.nix
@@ -0,0 +1,47 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchPypi,
+  hatchling,
+  importlib-metadata,
+  numpy,
+  platformdirs,
+  typing-extensions,
+  wasmtime,
+  writableTmpDirAsHomeHook,
+}:
+
+buildPythonPackage (finalAttrs: {
+  pname = "itkwasm";
+  version = "1.0b195";
+  pyproject = true;
+
+  src = fetchPypi {
+    inherit (finalAttrs) pname version;
+    hash = "sha256-1OQ0SieMEcrWiIgWT1dQxXdk9lCbWD+1xJ0jfIr0isU=";
+  };
+
+  build-system = [ hatchling ];
+
+  nativeBuildInputs = [ writableTmpDirAsHomeHook ];
+
+  dependencies = [
+    importlib-metadata
+    numpy
+    platformdirs
+    typing-extensions
+    wasmtime
+  ];
+
+  # No test available
+  doCheck = false;
+
+  pythonImportsCheck = [ "itkwasm" ];
+
+  meta = {
+    description = "Python interface to itk-wasm WebAssembly (Wasm) modules";
+    homepage = "https://pypi.org/project/itkwasm";
+    license = lib.licenses.asl20;
+    maintainers = with lib.maintainers; [ fab ];
+  };
+})
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 626f12dc1151..0ab96896d06f 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -7801,6 +7801,8 @@ self: super: with self; {
     }
   );
 
+  itkwasm = callPackage ../development/python-modules/itkwasm { };
+
   itsdangerous = callPackage ../development/python-modules/itsdangerous { };
 
   itunespy = callPackage ../development/python-modules/itunespy { };