diff --git a/pkgs/applications/radio/uhd/default.nix b/pkgs/applications/radio/uhd/default.nix
index 1fcb0e28031f..ffc28c3480f0 100644
--- a/pkgs/applications/radio/uhd/default.nix
+++ b/pkgs/applications/radio/uhd/default.nix
@@ -45,9 +45,10 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = [
     cmake
     pkgconfig
+    # Python + Mako are always required for the build itself but not necessary for runtime
+    (python.withPackages (ps: with ps; [ Mako ]))
   ];
   buildInputs = [
-    (python.withPackages (ps: with ps; [ Mako six requests ]))
     libusb1
     boost
   ];