diff --git a/pkgs/applications/radio/gnuradio/wrapper.nix b/pkgs/applications/radio/gnuradio/wrapper.nix
index f7b96b1c1b95..b226ce3d68d6 100644
--- a/pkgs/applications/radio/gnuradio/wrapper.nix
+++ b/pkgs/applications/radio/gnuradio/wrapper.nix
@@ -246,7 +246,7 @@ let
             mv -f "$i".tmp "$i"
             if head -1 "$i" | grep -q ${unwrapped.python}; then
               substituteInPlace "$i" \
-                --replace ${unwrapped.python} ${pythonEnv}
+                --replace-fail ${unwrapped.python} ${pythonEnv}
             fi
             wrapProgram "$i" ${makeWrapperArgs}
           done