diff --git a/pkgs/development/python-modules/autopxd2/default.nix b/pkgs/development/python-modules/autopxd2/default.nix
new file mode 100644
index 000000000000..4b9717679247
--- /dev/null
+++ b/pkgs/development/python-modules/autopxd2/default.nix
@@ -0,0 +1,48 @@
+{
+  buildPythonPackage,
+  lib,
+  fetchPypi,
+  setuptools,
+  pycparser,
+  click,
+  pytestCheckHook,
+  cython,
+}:
+
+buildPythonPackage rec {
+  pname = "python-autopxd2";
+  version = "2.5.0";
+  pyproject = true;
+
+  src = fetchPypi {
+    pname = "autopxd2";
+    inherit version;
+    hash = "sha256-uxVWz2LSXWpDYvQFrxlrmxA1XQagyHTfFf4hhaHKOqc=";
+  };
+
+  build-system = [
+    setuptools
+  ];
+
+  dependencies = [
+    pycparser
+    click
+    cython
+  ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+  ];
+
+  pytestFlagsArray = [
+    "test/"
+  ];
+
+  meta = {
+    homepage = "https://github.com/elijahr/python-autopxd2";
+    mainProgram = "autopxd";
+    maintainers = with lib.maintainers; [ bot-wxt1221 ];
+    license = lib.licenses.mit;
+    description = "Generates .pxd files automatically from .h files";
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 5a39088cd82f..74fc0cc05e26 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -1066,6 +1066,8 @@ self: super: with self; {
 
   autopep8 = callPackage ../development/python-modules/autopep8 { };
 
+  autopxd2 = callPackage ../development/python-modules/autopxd2 { };
+
   autoslot = callPackage ../development/python-modules/autoslot { };
 
   avahi = toPythonModule (pkgs.avahi.override {