diff --git a/pkgs/by-name/pd/pdfium-binaries/package.nix b/pkgs/by-name/pd/pdfium-binaries/package.nix
index 7b96a89ba2d8..b61b8b12d42f 100644
--- a/pkgs/by-name/pd/pdfium-binaries/package.nix
+++ b/pkgs/by-name/pd/pdfium-binaries/package.nix
@@ -8,7 +8,6 @@
 
 stdenv.mkDerivation (finalAttrs: {
   pname = "pdfium-binaries";
-  # also update rev of headers in python3Packages.pypdfium2
   version = "7363";
 
   src =
diff --git a/pkgs/development/python-modules/pypdfium2/default.nix b/pkgs/development/python-modules/pypdfium2/default.nix
index 8a566a791873..5acd2148dcce 100644
--- a/pkgs/development/python-modules/pypdfium2/default.nix
+++ b/pkgs/development/python-modules/pypdfium2/default.nix
@@ -1,10 +1,9 @@
 {
   stdenv,
   lib,
-  pkgs,
+  pkgsCross,
   buildPythonPackage,
   fetchFromGitHub,
-  fetchgit,
   gitUpdater,
   setuptools-scm,
   pdfium-binaries,
@@ -13,22 +12,9 @@
   pytestCheckHook,
   removeReferencesTo,
   python,
-  replaceVars,
 }:
 
 let
-  pdfiumVersion = "${pdfium-binaries.version}";
-
-  headers = fetchgit {
-    url = "https://pdfium.googlesource.com/pdfium";
-    # The latest revision on the chromium/${pdfiumVersion} branch
-    rev = "9232d7c94a0007377a8034222f47683fe391d474";
-    hash = "sha256-dI3jTyVYc0EmMLHTiVjGSf3C2noS9Ru5WijEJFtiSFk=";
-    sparseCheckout = [
-      "public"
-    ];
-  };
-
   # They demand their own fork of ctypesgen
   ctypesgen = buildPythonPackage rec {
     pname = "ctypesgen";
@@ -38,34 +24,26 @@ let
     src = fetchFromGitHub {
       owner = "pypdfium2-team";
       repo = "ctypesgen";
-      rev = "848e9fbb1374f7f58a7ebf5e5da5c33292480b30";
-      hash = "sha256-3JA7cW/xaEj/DxMHEypROwrKGo7EwUEcipRqALTvydw=";
+      rev = "3961621c3e057015362db82471e07f3a57822b15";
+      hash = "sha256-0OBY7/Zn12rG20jNYG65lANTRVRIFvE0SgUdYGFpRtU=";
     };
 
-    patches = [
-      (replaceVars ./fix-cc-detection.patch {
-        cc = "${stdenv.cc.targetPrefix}cc";
-      })
-    ];
-
     build-system = [
       setuptools-scm
     ];
-
-    env.SETUPTOOLS_SCM_PRETEND_VERSION = "${version}";
   };
 
 in
 buildPythonPackage rec {
   pname = "pypdfium2";
-  version = "4.30.1";
+  version = "5.0.0";
   pyproject = true;
 
   src = fetchFromGitHub {
     owner = "pypdfium2-team";
     repo = "pypdfium2";
     tag = version;
-    hash = "sha256-v8f/XruGJYK3H9z4Q1rLg4fEnPHa8tTOlNTBMVxPEgA=";
+    hash = "sha256-to6l8kfi6pYRs+hv+9zdxpSyhKCxX79G/EMdz6OBBaA=";
   };
 
   build-system = [
@@ -81,43 +59,19 @@ buildPythonPackage rec {
     pdfium-binaries
   ];
 
-  # Build system insists on fetching from the internet unless "cached" files
-  # are prepared. Even then, some code patching needs to happen to make it not
-  # talk to the internet.
+  preBuild = ''
+    getVersion() {
+      cat ${pdfium-binaries}/VERSION | grep $1 | sed 's/.*=//'
+    }
+    export GIVEN_FULLVER="$(getVersion MAJOR).$(getVersion MINOR).$(getVersion BUILD).$(getVersion PATCH)"
+  '';
 
-  # The project doesn't seem very open to allow for offline building either,
-  # see: https://github.com/pypdfium2-team/pypdfium2/discussions/274
-  preBuild =
-    let
-      pdfiumLib = lib.makeLibraryPath [ pdfium-binaries ];
-      inputVersionFile = (pkgs.formats.json { }).generate "version.json" {
-        version = lib.strings.toInt pdfiumVersion;
-        source = "generated";
-        flags = [ ];
-        run_lds = [ pdfiumLib ];
-        guard_symbols = false;
-      };
-      bindingsDir = "data/bindings";
-      headersDir = "${bindingsDir}/headers";
-      versionFile = "${bindingsDir}/version.json";
-    in
-    ''
-      # Preseed the headers and version file
-      mkdir -p ${bindingsDir}
-      cp -r ${headers}/public ${headersDir}
-      install -m 644 ${inputVersionFile} ${versionFile}
-
-      # Make generated bindings consider pdfium derivation path when loading dynamic libraries
-      substituteInPlace setupsrc/pypdfium2_setup/emplace.py \
-        --replace-fail 'build_pdfium_bindings(pdfium_ver, flags=flags, guard_symbols=True, run_lds=[])' \
-                       'build_pdfium_bindings(pdfium_ver, flags=flags, guard_symbols=True, run_lds=["${pdfiumLib}"])'
-
-      # Short circuit the version pull from the internet
-      substituteInPlace setupsrc/pypdfium2_setup/packaging_base.py \
-        --replace-fail 'PdfiumVer.to_full(build)._asdict()' \
-                       '{"major": 133, "minor": 0, "build": ${pdfiumVersion}, "patch": 1}'
-    '';
-  env.PDFIUM_PLATFORM = "system:${pdfiumVersion}";
+  env = {
+    PDFIUM_PLATFORM = "system-search:${pdfium-binaries.version}";
+    PDFIUM_HEADERS = "${pdfium-binaries}/include";
+    PDFIUM_BINARY = "${pdfium-binaries}/lib/libpdfium${stdenv.targetPlatform.extensions.sharedLibrary}";
+    CPP = "${stdenv.cc.targetPrefix}cpp";
+  };
 
   # Remove references to stdenv in comments.
   postInstall = ''
@@ -138,6 +92,7 @@ buildPythonPackage rec {
     updateScript = gitUpdater {
       allowedVersions = "^[.0-9]+$";
     };
+    tests.cross = pkgsCross.aarch64-multiplatform.python3Packages.pypdfium2;
   };
 
   meta = {
diff --git a/pkgs/development/python-modules/pypdfium2/fix-cc-detection.patch b/pkgs/development/python-modules/pypdfium2/fix-cc-detection.patch
deleted file mode 100644
index e01cc90901f5..000000000000
--- a/pkgs/development/python-modules/pypdfium2/fix-cc-detection.patch
+++ /dev/null
@@ -1,25 +0,0 @@
-diff --git a/src/ctypesgen/__main__.py b/src/ctypesgen/__main__.py
-index 23ee014..2d0cfc1 100644
---- a/src/ctypesgen/__main__.py
-+++ b/src/ctypesgen/__main__.py
-@@ -89,17 +89,9 @@ def main_impl(args, cmd_str):
-         assert _is_relative_to(args.output, args.linkage_anchor)
-     
-     if args.cpp:
--        assert shutil.which(args.cpp[0]), f"Given pre-processor {args.cpp[0]!r} is not available."
--    else:
--        if shutil.which("gcc"):
--            args.cpp = ["gcc", "-E"]
--        elif shutil.which("cpp"):
--            args.cpp = ["cpp"]
--        elif shutil.which("clang"):
--            args.cpp = ["clang", "-E"]
--        else:
--            raise RuntimeError("C pre-processor auto-detection failed: neither gcc nor clang available.")
--    
-+        print("cpp argument ignored for nix build")
-+    args.cpp = ["@cc@", "-E"]
-+ 
-     # Important: must not use +=, this would mutate the original object, which is problematic when default=[] is used and ctypesgen called repeatedly from within python
-     args.compile_libdirs = args.compile_libdirs + args.universal_libdirs
-     args.runtime_libdirs = args.runtime_libdirs + args.universal_libdirs