diff --git a/pkgs/tools/misc/screen/default.nix b/pkgs/tools/misc/screen/default.nix
index 45319b2b79a6..3c50af1fe6bf 100644
--- a/pkgs/tools/misc/screen/default.nix
+++ b/pkgs/tools/misc/screen/default.nix
@@ -11,33 +11,32 @@
 
 stdenv.mkDerivation rec {
   pname = "screen";
-  version = "4.9.1";
+  version = "5.0.0";
 
   src = fetchurl {
     url = "mirror://gnu/screen/screen-${version}.tar.gz";
-    hash = "sha256-Js7z48QlccDUhK1vrxEMXBUJH7+HKwb6eqR2bHQFrGk=";
+    hash = "sha256-8Eo50AoOXHyGpVM4gIkDCCrV301z3xov00JZdq7ZSXE=";
   };
 
   configureFlags = [
     "--enable-telnet"
     "--enable-pam"
-    "--with-sys-screenrc=/etc/screenrc"
-    "--enable-colors256"
-    "--enable-rxvt_osc"
   ];
 
+  # We need _GNU_SOURCE so that mallocmock_reset() is defined: https://savannah.gnu.org/bugs/?66416
+  NIX_CFLAGS_COMPILE = lib.optionalString (stdenv.cc.isGNU) "-D_GNU_SOURCE=1 -Wno-int-conversion -Wno-incompatible-pointer-types";
+
   nativeBuildInputs = [
     autoreconfHook
   ];
-  buildInputs =
-    [
-      ncurses
-      libxcrypt
-    ]
-    ++ lib.optional stdenv.hostPlatform.isLinux pam
-    ++ lib.optional stdenv.hostPlatform.isDarwin utmp;
+  buildInputs = [
+    ncurses
+    libxcrypt
+    pam
+  ] ++ lib.optional stdenv.hostPlatform.isDarwin utmp;
 
-  doCheck = true;
+  # The test suite seems to have some glibc malloc hooks that don't exist/link on macOS
+  doCheck = !stdenv.hostPlatform.isDarwin;
 
   meta = with lib; {
     homepage = "https://www.gnu.org/software/screen/";