diff --git a/pkgs/development/libraries/itk/5.x.nix b/pkgs/development/libraries/itk/5.x.nix
new file mode 100644
index 000000000000..e50f2bbca494
--- /dev/null
+++ b/pkgs/development/libraries/itk/5.x.nix
@@ -0,0 +1,5 @@
+import ./generic.nix rec {
+  version = "5.2.1";
+  rev = "v${version}";
+  sourceSha256 = "sha256-KaVe9FMGm4ZVMpwAT12fA67T0qZS3ZueiI8z85+xSwE=";
+}
diff --git a/pkgs/development/libraries/itk/default.nix b/pkgs/development/libraries/itk/generic.nix
similarity index 94%
rename from pkgs/development/libraries/itk/default.nix
rename to pkgs/development/libraries/itk/generic.nix
index 6816c37b9be6..0d742b393b1d 100644
--- a/pkgs/development/libraries/itk/default.nix
+++ b/pkgs/development/libraries/itk/generic.nix
@@ -1,9 +1,11 @@
+{ version, rev, sourceSha256 }:
+
 { lib, stdenv, fetchFromGitHub, cmake, makeWrapper
 , pkg-config, libX11, libuuid, xz, vtk, Cocoa }:
 
 stdenv.mkDerivation rec {
   pname = "itk";
-  version = "5.2.1";
+  inherit version;
 
   itkGenericLabelInterpolatorSrc = fetchFromGitHub {
     owner = "InsightSoftwareConsortium";
@@ -22,8 +24,8 @@ stdenv.mkDerivation rec {
   src = fetchFromGitHub {
     owner = "InsightSoftwareConsortium";
     repo = "ITK";
-    rev = "v${version}";
-    sha256 = "sha256-KaVe9FMGm4ZVMpwAT12fA67T0qZS3ZueiI8z85+xSwE=";
+    inherit rev;
+    sha256 = sourceSha256;
   };
 
   postPatch = ''
diff --git a/pkgs/development/libraries/itk/unstable.nix b/pkgs/development/libraries/itk/unstable.nix
new file mode 100644
index 000000000000..bb64d4afca9a
--- /dev/null
+++ b/pkgs/development/libraries/itk/unstable.nix
@@ -0,0 +1,5 @@
+import ./generic.nix {
+  version = "unstable-2022-07-02";
+  rev = "5e7aea957c82b67d4364b2b88999805616e3b01d";
+  sourceSha256 = "sha256-tjkoaHCuVdvgE6X+7Kb8mt9oxINWs4R0xD9cxdEeYKk=";
+}
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 0106424aa8eb..f969876f818e 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -18803,10 +18803,16 @@ with pkgs;
     inherit (darwin.apple_sdk.frameworks) Cocoa;
   };
 
-  itk = callPackage ../development/libraries/itk {
+  itk_5 = callPackage ../development/libraries/itk/5.x.nix {
     inherit (darwin.apple_sdk.frameworks) Cocoa;
   };
 
+  itk-unstable = callPackage ../development/libraries/itk/unstable.nix {
+    inherit (darwin.apple_sdk.frameworks) Cocoa;
+  };
+
+  itk = itk_5;
+
   jama = callPackage ../development/libraries/jama { };
 
   jansson = callPackage ../development/libraries/jansson { };