diff --git a/pkgs/development/python-modules/bz2file/default.nix b/pkgs/development/python-modules/bz2file/default.nix
deleted file mode 100644
index a98ddf851823..000000000000
--- a/pkgs/development/python-modules/bz2file/default.nix
+++ /dev/null
@@ -1,24 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchPypi,
-}:
-
-buildPythonPackage rec {
-  pname = "bz2file";
-  version = "0.98";
-  format = "setuptools";
-
-  src = fetchPypi {
-    inherit pname version;
-    sha256 = "126s53fkpx04f33a829yqqk8fj4png3qwg4m66cvlmhmwc8zihb4";
-  };
-
-  doCheck = false;
-  # The test module (test_bz2file) is not available
-
-  meta = {
-    description = "Bz2file is a Python library for reading and writing bzip2-compressed files";
-    license = lib.licenses.asl20;
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index fdb38432f1dd..4f0163fc3992 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -128,6 +128,7 @@ mapAliases ({
   bunch = throw "bunch has been removed as it is unmaintained since inception"; # added 2025-05-31
   btsmarthub_devicelist = btsmarthub-devicelist; # added 2024-01-03
   bt_proximity = bt-proximity; # added 2021-07-02
+  bz2file = throw "'bz2file' has beem removed, as it was not longed maintained upstream since 2020"; # added 2025-08-26
   BTrees = btrees; # added 2023-02-19
   cacheyou = throw "cacheyou has been removed, as it was no longer used for the only consumer pdm"; # added 2023-12-21
   cadquery = throw "cadquery was removed, because it was disabled on all python version since 3.8 and marked as broken"; # added 2024-05-13
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 65a5801b84bc..7e8657d1b2e1 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -2230,8 +2230,6 @@ self: super: with self; {
 
   bytewax = callPackage ../development/python-modules/bytewax { };
 
-  bz2file = callPackage ../development/python-modules/bz2file { };
-
   cache = callPackage ../development/python-modules/cache { };
 
   cachecontrol = callPackage ../development/python-modules/cachecontrol { };