diff --git a/pkgs/development/python-modules/mesa/default.nix b/pkgs/development/python-modules/mesa/default.nix
deleted file mode 100644
index c26bf68c8582..000000000000
--- a/pkgs/development/python-modules/mesa/default.nix
+++ /dev/null
@@ -1,51 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchPypi,
-  isPy27,
-  cookiecutter,
-  networkx,
-  pandas,
-  tornado,
-  tqdm,
-  pytestCheckHook,
-}:
-
-buildPythonPackage rec {
-  pname = "mesa";
-  version = "3.2.0";
-  format = "setuptools";
-
-  # According to their docs, this library is for Python 3+.
-  disabled = isPy27;
-
-  src = fetchPypi {
-    pname = "mesa";
-    inherit version;
-    hash = "sha256-k4UjkUGL4qDgOhucQU7svRNZtM3ZqtO6NUxpl4NhQl0=";
-  };
-
-  propagatedBuildInputs = [
-    cookiecutter
-    networkx
-    pandas
-    tornado
-    tqdm
-  ];
-
-  nativeCheckInputs = [ pytestCheckHook ];
-
-  disabledTests = [
-    "test_examples"
-    "test_run"
-    "test_scaffold_creates_project_dir"
-  ];
-
-  meta = with lib; {
-    homepage = "https://github.com/projectmesa/mesa";
-    description = "Agent-based modeling (or ABM) framework in Python";
-    license = licenses.asl20;
-    maintainers = [ maintainers.dpaetzel ];
-    broken = true; # missing dependencies
-  };
-}
diff --git a/pkgs/development/python-modules/pyglet/default.nix b/pkgs/development/python-modules/pyglet/default.nix
index 9948a21bdec6..ecf741205aea 100644
--- a/pkgs/development/python-modules/pyglet/default.nix
+++ b/pkgs/development/python-modules/pyglet/default.nix
@@ -18,7 +18,6 @@
   openal,
   libpulseaudio,
   harfbuzz,
-  mesa,
   apple-sdk,
 }:
 
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 5e7673c9deae..8b8feaa7e57d 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -443,6 +443,7 @@ mapAliases ({
   mathlibtools = throw "mathlibtools has been removed because the upstream repository was archived in 2023"; # added 2025-07-09
   matrix-api-async = throw "matrix-api-async has been removed as it is an old wrapper and no longer in use"; # added 2025-01-01
   memory_profiler = memory-profiler; # added 2023-10-09
+  mesa = throw "python3Packages.mesa has been removed because it has been marked as broken since at least November 2024."; # Added 2025-10-03
   mir_eval = mir-eval; # added 2024-01-07
   mistune_0_8 = throw "mistune_0_8 was removed because it was outdated and insecure"; # added 2022-08-12
   mistune_2_0 = mistune; # added 2022-08-12
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 4dc67b8ebc8e..64f7de775471 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -9231,8 +9231,6 @@ self: super: with self; {
 
   meross-iot = callPackage ../development/python-modules/meross-iot { };
 
-  mesa = callPackage ../development/python-modules/mesa { };
-
   meshcat = callPackage ../development/python-modules/meshcat { };
 
   meshcore = callPackage ../development/python-modules/meshcore { };
@@ -9594,7 +9592,9 @@ self: super: with self; {
 
   moderngl = callPackage ../development/python-modules/moderngl { };
 
-  moderngl-window = callPackage ../development/python-modules/moderngl-window { };
+  moderngl-window = callPackage ../development/python-modules/moderngl-window {
+    inherit (pkgs) mesa;
+  };
 
   moehlenhoff-alpha2 = callPackage ../development/python-modules/moehlenhoff-alpha2 { };
 
@@ -13671,7 +13671,9 @@ self: super: with self; {
 
   pyopencl = callPackage ../development/python-modules/pyopencl { };
 
-  pyopengl = callPackage ../development/python-modules/pyopengl { };
+  pyopengl = callPackage ../development/python-modules/pyopengl {
+    inherit (pkgs) mesa;
+  };
 
   pyopengl-accelerate = callPackage ../development/python-modules/pyopengl-accelerate { };
 
@@ -13876,7 +13878,9 @@ self: super: with self; {
 
   pyqt5-multimedia = self.pyqt5.override { withMultimedia = true; };
 
-  pyqt5-sip = callPackage ../development/python-modules/pyqt/sip.nix { };
+  pyqt5-sip = callPackage ../development/python-modules/pyqt/sip.nix {
+    inherit (pkgs) mesa;
+  };
 
   pyqt5-stubs = callPackage ../development/python-modules/pyqt5-stubs { };
 
@@ -13885,13 +13889,21 @@ self: super: with self; {
   # `propagatedBuildInputs` may cause collisions.
   pyqt5-webkit = self.pyqt5.override { withWebKit = true; };
 
-  pyqt6 = callPackage ../development/python-modules/pyqt/6.x.nix { };
+  pyqt6 = callPackage ../development/python-modules/pyqt/6.x.nix {
+    inherit (pkgs) mesa;
+  };
 
-  pyqt6-charts = callPackage ../development/python-modules/pyqt6-charts { };
+  pyqt6-charts = callPackage ../development/python-modules/pyqt6-charts {
+    inherit (pkgs) mesa;
+  };
 
-  pyqt6-sip = callPackage ../development/python-modules/pyqt/pyqt6-sip.nix { };
+  pyqt6-sip = callPackage ../development/python-modules/pyqt/pyqt6-sip.nix {
+    inherit (pkgs) mesa;
+  };
 
-  pyqt6-webengine = callPackage ../development/python-modules/pyqt6-webengine { };
+  pyqt6-webengine = callPackage ../development/python-modules/pyqt6-webengine {
+    inherit (pkgs) mesa;
+  };
 
   pyqtchart = pkgs.libsForQt5.callPackage ../development/python-modules/pyqtchart {
     inherit (self)
@@ -13923,7 +13935,9 @@ self: super: with self; {
 
   pyqtgraph = callPackage ../development/python-modules/pyqtgraph { };
 
-  pyqtwebengine = callPackage ../development/python-modules/pyqtwebengine { };
+  pyqtwebengine = callPackage ../development/python-modules/pyqtwebengine {
+    inherit (pkgs) mesa;
+  };
 
   pyquaternion = callPackage ../development/python-modules/pyquaternion { };