diff --git a/nixos/doc/manual/release-notes/rl-2611.section.md b/nixos/doc/manual/release-notes/rl-2611.section.md
index 3697b3bb2e3e..64e2c427da94 100644
--- a/nixos/doc/manual/release-notes/rl-2611.section.md
+++ b/nixos/doc/manual/release-notes/rl-2611.section.md
@@ -34,6 +34,8 @@
 
 - `services.firezone.server.provision` has been removed due to it being unmaintanable. Remove all uses of provisioning and use the WebUI to configure firezone.
 
+- The `services.syncthing` module now updates the Syncthing REST API using partial updates (`PATCH`) instead of full replacements (`PUT`) for general settings. Updating these settings was broken and prone to errors after updates, see [#428808](https://github.com/NixOS/nixpkgs/issues/428808) and [#528889](https://github.com/NixOS/nixpkgs/issues/528889). As a result, settings modified manually through the Syncthing Web UI that are not explicitly defined in your Nix configuration will now persist across rebuilds.
+
 ## Other Notable Changes {#sec-release-26.11-notable-changes}
 
 <!-- To avoid merge conflicts, consider adding your item at an arbitrary place in the list instead. -->
diff --git a/nixos/modules/services/networking/syncthing.nix b/nixos/modules/services/networking/syncthing.nix
index 6925950a048f..17594e8db9f9 100644
--- a/nixos/modules/services/networking/syncthing.nix
+++ b/nixos/modules/services/networking/syncthing.nix
@@ -312,7 +312,7 @@ let
           "defaults"
         ])
         (map (subOption: ''
-          curl -X PUT -d ${
+          curl -X PATCH -d ${
             lib.escapeShellArg (builtins.toJSON cleanedConfig.${subOption})
           } ${curlAddressArgs "/rest/config/${subOption}"}
         ''))
@@ -323,11 +323,18 @@ let
       (lib.optionalString (cleanedConfig ? defaults) (
         lib.pipe cleanedConfig.defaults [
           builtins.attrNames
-          (map (subOption: ''
-            curl -X PUT -d ${
-              lib.escapeShellArg (builtins.toJSON cleanedConfig.defaults.${subOption})
-            } ${curlAddressArgs "/rest/config/defaults/${subOption}"}
-          ''))
+          (map (
+            subOption:
+            let
+              # /rest/config/defaults/ignores only supports PUT
+              method = if subOption == "ignores" then "PUT" else "PATCH";
+            in
+            ''
+              curl -X ${method} -d ${
+                lib.escapeShellArg (builtins.toJSON cleanedConfig.defaults.${subOption})
+              } ${curlAddressArgs "/rest/config/defaults/${subOption}"}
+            ''
+          ))
           (lib.concatStringsSep "\n")
         ]
       ))