diff --git a/pkgs/applications/science/molecular-dynamics/gromacs/default.nix b/pkgs/applications/science/molecular-dynamics/gromacs/default.nix
index c05e79eebcdf..fe4d965b7778 100644
--- a/pkgs/applications/science/molecular-dynamics/gromacs/default.nix
+++ b/pkgs/applications/science/molecular-dynamics/gromacs/default.nix
@@ -19,6 +19,10 @@
 , cpuAcceleration ? null
 }:
 
+
+# CUDA is only implemented for single precission
+assert enableCuda -> singlePrec;
+
 let
   inherit (cudaPackages.cudaFlags) cudaCapabilities dropDot;