diff --git a/pkgs/tools/misc/diffoscope/default.nix b/pkgs/tools/misc/diffoscope/default.nix
index 069343b8a478..82c6bbebe774 100644
--- a/pkgs/tools/misc/diffoscope/default.nix
+++ b/pkgs/tools/misc/diffoscope/default.nix
@@ -38,7 +38,7 @@ python3Packages.buildPythonApplication rec {
   # Still missing these tools: docx2txt dumpimage dumppdf dumpxsb enjarify lipo ocamlobjinfo oggDump otool procyon
   pythonPath = [
       binutils-unwrapped bzip2 colordiff coreutils cpio db diffutils
-      dtc e2fsprogs file findutils fontforge-fonttools gettext gnutar gzip
+      e2fsprogs file findutils fontforge-fonttools gettext gnutar gzip
       libarchive libcaca lz4 openssl pgpdump sng sqlite squashfsTools unzip xxd
       xz zip zstd
     ]
@@ -46,7 +46,7 @@ python3Packages.buildPythonApplication rec {
       argcomplete debian defusedxml jsondiff jsbeautifier libarchive-c
       python_magic progressbar33 pypdf2 rpm tlsh
     ])
-    ++ lib.optionals stdenv.isLinux [ python3Packages.pyxattr acl cdrkit ]
+    ++ lib.optionals stdenv.isLinux [ python3Packages.pyxattr acl cdrkit dtc ]
     ++ lib.optionals enableBloat ([
       abootimg apksigner apktool cbfstool colord ffmpeg fpc ghc ghostscriptX giflib gnupg gnumeric
       hdf5 imagemagick llvm jdk mono odt2txt openssh pdftk poppler_utils qemu R tcpdump wabt radare2
@@ -70,6 +70,19 @@ python3Packages.buildPythonApplication rec {
     # Failing because of file-v5.40 has a slightly different output.
     # Upstream issue: https://salsa.debian.org/reproducible-builds/diffoscope/-/issues/271
     "test_text_proper_indentation"
+  ] ++ lib.optionals stdenv.isDarwin [
+    # Disable flaky tests on Darwin
+    "test_non_unicode_filename"
+    "test_listing"
+  ];
+
+  # flaky tests on Darwin
+  disabledTestPaths = lib.optionals stdenv.isDarwin [
+    "tests/comparators/test_git.py"
+    "tests/comparators/test_java.py"
+    "tests/comparators/test_uimage.py"
+    "tests/comparators/test_device.py"
+    "tests/comparators/test_macho.py"
   ];
 
   meta = with lib; {
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 585235b9afd6..dd794b158777 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -4252,7 +4252,7 @@ with pkgs;
   };
 
   diffoscope = diffoscopeMinimal.override {
-    enableBloat = true;
+    enableBloat = !stdenv.isDarwin;
   };
 
   diffr = callPackage ../tools/text/diffr {