diff --git a/pkgs/by-name/ce/cewler/package.nix b/pkgs/by-name/ce/cewler/package.nix
index f4f96039b9f6..92399307e6a7 100644
--- a/pkgs/by-name/ce/cewler/package.nix
+++ b/pkgs/by-name/ce/cewler/package.nix
@@ -19,7 +19,6 @@ python3.pkgs.buildPythonApplication rec {
   nativeBuildInputs = with python3.pkgs; [
     setuptools
     wheel
-    pythonRelaxDepsHook
   ];
 
   propagatedBuildInputs = with python3.pkgs; [
diff --git a/pkgs/by-name/sh/sherlock/package.nix b/pkgs/by-name/sh/sherlock/package.nix
index 9d96cc3da382..50421ff991b6 100644
--- a/pkgs/by-name/sh/sherlock/package.nix
+++ b/pkgs/by-name/sh/sherlock/package.nix
@@ -64,7 +64,6 @@ python3.pkgs.buildPythonApplication rec {
     jsonschema
     openpyxl
     stem
-    pythonRelaxDepsHook
   ];
 
   pythonRelaxDeps = [ "stem" ];
diff --git a/pkgs/by-name/zo/zotify/package.nix b/pkgs/by-name/zo/zotify/package.nix
index d5250b780a42..c6704ab2e53a 100644
--- a/pkgs/by-name/zo/zotify/package.nix
+++ b/pkgs/by-name/zo/zotify/package.nix
@@ -20,8 +20,6 @@ python3Packages.buildPythonApplication rec {
 
   build-system = [ python3Packages.setuptools ];
 
-  nativeBuildInputs = [ python3Packages.pythonRelaxDepsHook ];
-
   pythonRelaxDeps = [ "protobuf" ];
 
   dependencies = with python3Packages; [
diff --git a/pkgs/development/python-modules/datashaper/default.nix b/pkgs/development/python-modules/datashaper/default.nix
index 1da7346f2669..3ad28d2228ed 100644
--- a/pkgs/development/python-modules/datashaper/default.nix
+++ b/pkgs/development/python-modules/datashaper/default.nix
@@ -3,7 +3,6 @@
   buildPythonPackage,
   fetchPypi,
   pythonOlder,
-  pythonRelaxDepsHook,
   poetry-core,
   dacite,
   diskcache,
@@ -26,8 +25,6 @@ buildPythonPackage rec {
 
   build-system = [ poetry-core ];
 
-  nativeBuildInputs = [ pythonRelaxDepsHook ];
-
   pythonRelaxDeps = [ "pyarrow" ];
 
   dependencies = [
diff --git a/pkgs/development/python-modules/discum/default.nix b/pkgs/development/python-modules/discum/default.nix
index acc3a6e49a03..ffa8b9957993 100644
--- a/pkgs/development/python-modules/discum/default.nix
+++ b/pkgs/development/python-modules/discum/default.nix
@@ -3,7 +3,6 @@
   buildPythonPackage,
   fetchPypi,
   setuptools,
-  pythonRelaxDepsHook,
   brotli,
   colorama,
   filetype,
@@ -28,8 +27,6 @@ buildPythonPackage rec {
 
   build-system = [ setuptools ];
 
-  nativeBuildInputs = [ pythonRelaxDepsHook ];
-
   dependencies = [
     brotli
     colorama
diff --git a/pkgs/development/python-modules/h5py/default.nix b/pkgs/development/python-modules/h5py/default.nix
index 13a464dccb4c..14f7532f8c56 100644
--- a/pkgs/development/python-modules/h5py/default.nix
+++ b/pkgs/development/python-modules/h5py/default.nix
@@ -7,7 +7,6 @@
   setuptools,
   numpy,
   hdf5,
-  pythonRelaxDepsHook,
   cython_0,
   pkgconfig,
   mpi4py ? null,
@@ -15,7 +14,6 @@
   pytestCheckHook,
   pytest-mpi,
   cached-property,
-  stdenv,
 }:
 
 assert hdf5.mpiSupport -> mpi4py != null && hdf5.mpi == mpi4py.mpi;
@@ -67,7 +65,6 @@ buildPythonPackage rec {
   preBuild = lib.optionalString mpiSupport "export CC=${lib.getDev mpi}/bin/mpicc";
 
   nativeBuildInputs = [
-    pythonRelaxDepsHook
     cython_0
     pkgconfig
     setuptools
diff --git a/pkgs/development/python-modules/ibm-cloud-sdk-core/default.nix b/pkgs/development/python-modules/ibm-cloud-sdk-core/default.nix
index 9acf56259bc8..81ce3ddee218 100644
--- a/pkgs/development/python-modules/ibm-cloud-sdk-core/default.nix
+++ b/pkgs/development/python-modules/ibm-cloud-sdk-core/default.nix
@@ -7,7 +7,6 @@
   python-dateutil,
   pythonAtLeast,
   pythonOlder,
-  pythonRelaxDepsHook,
   requests,
   responses,
   setuptools,
@@ -29,8 +28,6 @@ buildPythonPackage rec {
 
   build-system = [ setuptools ];
 
-  nativeBuildInputs = [ pythonRelaxDepsHook ];
-
   dependencies = [
     pyjwt
     python-dateutil
diff --git a/pkgs/development/python-modules/samarium/default.nix b/pkgs/development/python-modules/samarium/default.nix
index 89d5a700a7bc..9e32e1c5b5df 100644
--- a/pkgs/development/python-modules/samarium/default.nix
+++ b/pkgs/development/python-modules/samarium/default.nix
@@ -5,7 +5,6 @@
   poetry-core,
   crossandra,
   dahlia,
-  pythonRelaxDepsHook
 }:
 
 buildPythonPackage rec {
@@ -20,11 +19,9 @@ buildPythonPackage rec {
     hash = "sha256-sOkJ67B8LaIA2cwCHaFnc16lMG8uaegBJCzF6Li77vk=";
   };
 
-  build-system = [ poetry-core pythonRelaxDepsHook ];
+  build-system = [ poetry-core ];
   dependencies = [ crossandra dahlia ];
 
-  pythonRelaxDeps = [ "crossandra" ];
-
   meta = with lib; {
     changelog = "https://github.com/samarium-lang/samarium/blob/${src.rev}/CHANGELOG.md";
     description = "The Samarium Programming Language";
diff --git a/pkgs/development/python-modules/spatialmath-python/default.nix b/pkgs/development/python-modules/spatialmath-python/default.nix
index 3613763f3105..f889c325ac2e 100644
--- a/pkgs/development/python-modules/spatialmath-python/default.nix
+++ b/pkgs/development/python-modules/spatialmath-python/default.nix
@@ -17,7 +17,6 @@
   pytest-xvfb,
   sympy,
   pytestCheckHook,
-  pythonRelaxDepsHook,
 }:
 
 buildPythonPackage rec {
@@ -36,7 +35,6 @@ buildPythonPackage rec {
   nativeBuildInputs = [
     oldest-supported-numpy
     setuptools
-    pythonRelaxDepsHook
   ];
 
   pythonRemoveDeps = [ "pre-commit" ];