diff --git a/pkgs/servers/monitoring/zabbix/agent2.nix b/pkgs/servers/monitoring/zabbix/agent2.nix
index b1bf7cd6f22f..e4e009cc64a7 100644
--- a/pkgs/servers/monitoring/zabbix/agent2.nix
+++ b/pkgs/servers/monitoring/zabbix/agent2.nix
@@ -14,7 +14,6 @@ import ./versions.nix (
   {
     version,
     hash,
-    vendorHash ? throw "unsupported version ${version} for zabbix-agent2",
     ...
   }:
   buildGoModule {
@@ -28,7 +27,7 @@ import ./versions.nix (
 
     modRoot = "src/go";
 
-    inherit vendorHash;
+    vendorHash = null;
 
     nativeBuildInputs = [
       autoreconfHook
diff --git a/pkgs/servers/monitoring/zabbix/server.nix b/pkgs/servers/monitoring/zabbix/server.nix
index 03cfae182aa4..54968b0bd4ff 100644
--- a/pkgs/servers/monitoring/zabbix/server.nix
+++ b/pkgs/servers/monitoring/zabbix/server.nix
@@ -91,10 +91,6 @@ import ./versions.nix (
       ++ optional postgresqlSupport "--with-postgresql"
       ++ optional ipmiSupport "--with-openipmi=${openipmi.dev}";
 
-    env.NIX_CFLAGS_COMPILE = lib.optionalString (
-      lib.versions.major version <= "5"
-    ) "-Wno-error=incompatible-pointer-types";
-
     prePatch = ''
       find database -name data.sql -exec sed -i 's|/usr/bin/||g' {} +
     '';
diff --git a/pkgs/servers/monitoring/zabbix/versions.nix b/pkgs/servers/monitoring/zabbix/versions.nix
index 64359e034b37..c477c85ec87f 100644
--- a/pkgs/servers/monitoring/zabbix/versions.nix
+++ b/pkgs/servers/monitoring/zabbix/versions.nix
@@ -2,27 +2,13 @@ generic: {
   v72 = generic {
     version = "7.2.5";
     hash = "sha256-DQGzk90isqYLNvs3qY/PEIHGg62Ygyot3YeUOhIAg54=";
-    vendorHash = null;
   };
   v70 = generic {
     version = "7.0.11";
     hash = "sha256-r9VNy3bRuFvJAL+ZQEbKjCAS3+AvetnWAwFjLxFVuGU=";
-    vendorHash = null;
-  };
-  v64 = generic {
-    version = "6.4.20";
-    hash = "sha256-tFsg2Jq8Uaa5YULGUu1kXLkxyJuA3YGeSfJ4DPfOHkk=";
-    vendorHash = null;
   };
   v60 = generic {
     version = "6.0.36";
     hash = "sha256-Ne0OY6NGzTYOn3sDVd+5tfawBu5VBjxNRtlxasubGCk=";
-    vendorHash = null;
-  };
-
-  v50 = generic {
-    version = "5.0.46";
-    hash = "sha256-p6OZALpOQG6v70Y20cC2bdlzTINz3JBd9qGWZACfcl4=";
-    vendorHash = "sha256-NgSi6usIbss3WEZCYht46WjxcrdOO3qv8KwwUZwtkk0=";
   };
 }
diff --git a/pkgs/servers/monitoring/zabbix/web.nix b/pkgs/servers/monitoring/zabbix/web.nix
index 7cbefe782637..a447c6e6b74f 100644
--- a/pkgs/servers/monitoring/zabbix/web.nix
+++ b/pkgs/servers/monitoring/zabbix/web.nix
@@ -24,7 +24,7 @@ import ./versions.nix (
 
     installPhase = ''
       mkdir -p $out/share/zabbix/
-      cp -a ${if lib.versionAtLeast version "5.0.0" then "ui/." else "frontends/php/."} $out/share/zabbix/
+      cp -a ui/. $out/share/zabbix/
       cp ${phpConfig} $out/share/zabbix/conf/zabbix.conf.php
     '';
 
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index 4e22c6ac92e1..57291469d208 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -1928,6 +1928,8 @@ mapAliases {
 
   ### Z ###
 
+  zabbix50 = throw "'zabbix50' has been removed, it would have reached its End of Life a few days after the release of NixOS 25.05. Consider upgrading to 'zabbix60' or 'zabbix70'.";
+  zabbix64 = throw "'zabbix64' has been removed because it reached its End of Life. Consider upgrading to 'zabbix70'.";
   zeroadPackages = recurseIntoAttrs {
     zeroad = lib.warnOnInstantiate "'zeroadPackages.zeroad' has been renamed to 'zeroad'" zeroad; # Added 2025-03-22
     zeroad-data = lib.warnOnInstantiate "'zeroadPackages.zeroad-data' has been renamed to 'zeroad-data'" zeroad-data; # Added 2025-03-22
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 15866dc68366..df0d13442b07 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -12577,8 +12577,6 @@ with pkgs;
   zabbix72 = recurseIntoAttrs (zabbixFor "v72");
   zabbix70 = recurseIntoAttrs (zabbixFor "v70");
   zabbix60 = recurseIntoAttrs (zabbixFor "v60");
-  zabbix64 = recurseIntoAttrs (zabbixFor "v64");
-  zabbix50 = recurseIntoAttrs (zabbixFor "v50");
 
   zabbix = zabbix60;