diff --git a/pkgs/applications/science/misc/root/default.nix b/pkgs/applications/science/misc/root/default.nix
index 41240a191cf9..e7188e7672c4 100644
--- a/pkgs/applications/science/misc/root/default.nix
+++ b/pkgs/applications/science/misc/root/default.nix
@@ -48,6 +48,7 @@
 , patchRcPathFish
 , patchRcPathPosix
 , tbb
+, xrootd
 , Cocoa
 , CoreSymbolication
 , OpenGL
@@ -113,6 +114,7 @@ stdenv.mkDerivation rec {
     patchRcPathPosix
     python.pkgs.numpy
     tbb
+    xrootd
   ]
   ++ lib.optionals (!stdenv.isDarwin) [ libX11 libXpm libXft libXext libGLU libGL ]
   ++ lib.optionals (stdenv.isDarwin) [ Cocoa CoreSymbolication OpenGL ]
@@ -195,7 +197,7 @@ stdenv.mkDerivation rec {
     "-Dvdt=OFF"
     "-Dwebgui=OFF"
     "-Dxml=ON"
-    "-Dxrootd=OFF"
+    "-Dxrootd=ON"
   ]
   ++ lib.optional (stdenv.cc.libc != null) "-DC_INCLUDE_DIRS=${lib.getDev stdenv.cc.libc}/include"
   ++ lib.optionals stdenv.isDarwin [
@@ -209,11 +211,13 @@ stdenv.mkDerivation rec {
 
   NIX_LDFLAGS = lib.optionalString (stdenv.isLinux && stdenv.isAarch64 && stdenv.cc.isGNU) "-lgcc";
 
+  # Workaround the xrootd runpath bug #169677 by prefixing [DY]LD_LIBRARY_PATH with ${lib.makeLibraryPath xrootd}.
+  # TODO: Remove the [DY]LDLIBRARY_PATH prefix for xrootd when #200830 get merged.
   postInstall = ''
     for prog in rootbrowse rootcp rooteventselector rootls rootmkdir rootmv rootprint rootrm rootslimtree; do
       wrapProgram "$out/bin/$prog" \
         --set PYTHONPATH "$out/lib" \
-        --set ${lib.optionalString stdenv.isDarwin "DY"}LD_LIBRARY_PATH "$out/lib"
+        --set ${lib.optionalString stdenv.isDarwin "DY"}LD_LIBRARY_PATH "$out/lib:${lib.makeLibraryPath [ xrootd ]}"
     done
 
     # Make ldd and sed available to the ROOT executable by prefixing PATH.
@@ -222,7 +226,8 @@ stdenv.mkDerivation rec {
         gnused # sed
         stdenv.cc # c++ ld etc.
         stdenv.cc.libc # ldd
-      ]}"
+      ]}" \
+      --prefix ${lib.optionalString stdenv.hostPlatform.isDarwin "DY"}LD_LIBRARY_PATH : "${lib.makeLibraryPath [ xrootd ]}"
 
     # Patch thisroot.{sh,csh,fish}