diff --git a/pkgs/by-name/ap/apbs/package.nix b/pkgs/by-name/ap/apbs/package.nix
index 4a7a06f18292..1b367e4fd744 100644
--- a/pkgs/by-name/ap/apbs/package.nix
+++ b/pkgs/by-name/ap/apbs/package.nix
@@ -27,8 +27,10 @@ let
       cmake
     ];
 
-    # Required for gcc-15 compatibility
-    env.NIX_CFLAGS_COMPILE = "-std=gnu17";
+    env = lib.optionalAttrs (!stdenv.hostPlatform.isDarwin) {
+      # Required for gcc-15 compatibility
+      NIX_CFLAGS_COMPILE = "-std=gnu17";
+    };
 
     cmakeFlags = [
       "-DBLAS_LIBRARIES=${blas}/lib"