diff --git a/pkgs/applications/science/biology/EZminc/default.nix b/pkgs/applications/science/biology/EZminc/default.nix
index 6c140b03ee4b..a4bb8c62f1c4 100644
--- a/pkgs/applications/science/biology/EZminc/default.nix
+++ b/pkgs/applications/science/biology/EZminc/default.nix
@@ -1,4 +1,4 @@
-{ lib, stdenv, fetchFromGitHub, cmake, pkg-config, libminc, bicpl, itk4, fftwFloat, gsl }:
+{ lib, stdenv, fetchFromGitHub, cmake, pkg-config, libminc, bicpl, itk, fftwFloat, gsl }:
 
 stdenv.mkDerivation rec {
   pname = "EZminc";
@@ -12,7 +12,7 @@ stdenv.mkDerivation rec {
   };
 
   nativeBuildInputs = [ cmake pkg-config ];
-  buildInputs = [ itk4 libminc bicpl fftwFloat gsl ];
+  buildInputs = [ itk libminc bicpl fftwFloat gsl ];
 
   cmakeFlags = [ "-DLIBMINC_DIR=${libminc}/lib/cmake"
                  "-DEZMINC_BUILD_TOOLS=TRUE"
diff --git a/pkgs/applications/science/biology/ants/default.nix b/pkgs/applications/science/biology/ants/default.nix
index ac332f271662..873cb28b5161 100644
--- a/pkgs/applications/science/biology/ants/default.nix
+++ b/pkgs/applications/science/biology/ants/default.nix
@@ -1,26 +1,18 @@
-{ lib, stdenv, fetchFromGitHub, fetchpatch, cmake, makeWrapper, itk4, vtk_7, Cocoa }:
+{ lib, stdenv, fetchFromGitHub, cmake, makeWrapper, itk-unstable, vtk_8, Cocoa }:
 
 stdenv.mkDerivation rec {
   pname    = "ANTs";
-  version = "2.2.0";
+  version = "2.4.1";
 
   src = fetchFromGitHub {
     owner  = "ANTsX";
     repo   = "ANTs";
-    rev    = "37ad4e20be3a5ecd26c2e4e41b49e778a0246c3d";
-    sha256 = "1hrdwv3m9xh3yf7l0rm2ggxc2xzckfb8srs88g485ibfszx7i03q";
+    rev    = "v${version}";
+    sha256 = "sha256-sRZwRRqqU0xiu4K6xlLQV4xzVNnzMlnRsk+TPiv0wD0=";
   };
 
-  patches = [
-    # Fix build with gcc8
-    (fetchpatch {
-      url = "https://github.com/ANTsX/ANTs/commit/89af9b2694715bf8204993e032fa132f80cf37bd.patch";
-      sha256 = "1glkrwa1jmxxbmzihycxr576azjqby31jwpj165qc54c91pn0ams";
-    })
-  ];
-
   nativeBuildInputs = [ cmake makeWrapper ];
-  buildInputs = [ itk4 vtk_7 ] ++ lib.optionals stdenv.isDarwin [ Cocoa ];
+  buildInputs = [ itk-unstable vtk_8 ] ++ lib.optionals stdenv.isDarwin [ Cocoa ];
 
   cmakeFlags = [ "-DANTS_SUPERBUILD=FALSE" "-DUSE_VTK=TRUE" ];
 
diff --git a/pkgs/development/libraries/itk/4.x.nix b/pkgs/development/libraries/itk/4.x.nix
deleted file mode 100644
index 54a3c33cd017..000000000000
--- a/pkgs/development/libraries/itk/4.x.nix
+++ /dev/null
@@ -1,35 +0,0 @@
-{ lib, stdenv, fetchFromGitHub, cmake, libX11, libuuid, xz, vtk_7, Cocoa }:
-
-stdenv.mkDerivation rec {
-  pname = "itk";
-  version = "4.13.3";
-
-  src = fetchFromGitHub {
-    owner = "InsightSoftwareConsortium";
-    repo = "ITK";
-    rev = "v${version}";
-    sha256 = "067vkh39jxcvyvn69qjh4vi3wa7vdvm9m6qsg3jmnmm7gzw0kjlm";
-  };
-
-  cmakeFlags = [
-    "-DBUILD_TESTING=OFF"
-    "-DBUILD_EXAMPLES=OFF"
-    "-DBUILD_SHARED_LIBS=ON"
-    "-DModule_ITKMINC=ON"
-    "-DModule_ITKIOMINC=ON"
-    "-DModule_ITKIOTransformMINC=ON"
-    "-DModule_ITKVtkGlue=ON"
-    "-DModule_ITKReview=ON"
-  ];
-
-  nativeBuildInputs = [ cmake xz ];
-  buildInputs = [ libX11 libuuid vtk_7 ] ++ lib.optionals stdenv.isDarwin [ Cocoa ];
-
-  meta = {
-    description = "Insight Segmentation and Registration Toolkit";
-    homepage = "https://www.itk.org/";
-    license = lib.licenses.asl20;
-    maintainers = with lib.maintainers; [viric];
-    platforms = with lib.platforms; linux ++ darwin;
-  };
-}
diff --git a/pkgs/development/libraries/itk/5.x.nix b/pkgs/development/libraries/itk/5.x.nix
new file mode 100644
index 000000000000..e50f2bbca494
--- /dev/null
+++ b/pkgs/development/libraries/itk/5.x.nix
@@ -0,0 +1,5 @@
+import ./generic.nix rec {
+  version = "5.2.1";
+  rev = "v${version}";
+  sourceSha256 = "sha256-KaVe9FMGm4ZVMpwAT12fA67T0qZS3ZueiI8z85+xSwE=";
+}
diff --git a/pkgs/development/libraries/itk/default.nix b/pkgs/development/libraries/itk/generic.nix
similarity index 94%
rename from pkgs/development/libraries/itk/default.nix
rename to pkgs/development/libraries/itk/generic.nix
index 6816c37b9be6..0d742b393b1d 100644
--- a/pkgs/development/libraries/itk/default.nix
+++ b/pkgs/development/libraries/itk/generic.nix
@@ -1,9 +1,11 @@
+{ version, rev, sourceSha256 }:
+
 { lib, stdenv, fetchFromGitHub, cmake, makeWrapper
 , pkg-config, libX11, libuuid, xz, vtk, Cocoa }:
 
 stdenv.mkDerivation rec {
   pname = "itk";
-  version = "5.2.1";
+  inherit version;
 
   itkGenericLabelInterpolatorSrc = fetchFromGitHub {
     owner = "InsightSoftwareConsortium";
@@ -22,8 +24,8 @@ stdenv.mkDerivation rec {
   src = fetchFromGitHub {
     owner = "InsightSoftwareConsortium";
     repo = "ITK";
-    rev = "v${version}";
-    sha256 = "sha256-KaVe9FMGm4ZVMpwAT12fA67T0qZS3ZueiI8z85+xSwE=";
+    inherit rev;
+    sha256 = sourceSha256;
   };
 
   postPatch = ''
diff --git a/pkgs/development/libraries/itk/unstable.nix b/pkgs/development/libraries/itk/unstable.nix
new file mode 100644
index 000000000000..bb64d4afca9a
--- /dev/null
+++ b/pkgs/development/libraries/itk/unstable.nix
@@ -0,0 +1,5 @@
+import ./generic.nix {
+  version = "unstable-2022-07-02";
+  rev = "5e7aea957c82b67d4364b2b88999805616e3b01d";
+  sourceSha256 = "sha256-tjkoaHCuVdvgE6X+7Kb8mt9oxINWs4R0xD9cxdEeYKk=";
+}
diff --git a/pkgs/development/libraries/vtk/7.x.nix b/pkgs/development/libraries/vtk/7.x.nix
deleted file mode 100644
index 615553f80f22..000000000000
--- a/pkgs/development/libraries/vtk/7.x.nix
+++ /dev/null
@@ -1,22 +0,0 @@
-import ./generic.nix {
-  majorVersion = "7.1";
-  minorVersion = "1";
-  sourceSha256 = "0nm7xwwj7rnsxjdv2ssviys8nhci4n9iiiqm2y14s520hl2dsp1d";
-  patchesToFetch = [
-    {
-      url = "https://gitlab.kitware.com/vtk/vtk/-/commit/706f1b397df09a27ab8981ab9464547028d0c322.diff";
-      sha256 = "1q3pi5h40g05pzpbqp75xlgzvbfvyw8raza51svmi7d8dlslqybx";
-    }
-
-    {
-      url = "https://gitweb.gentoo.org/repo/gentoo.git/plain/sci-libs/vtk/files/vtk-8.2.0-gcc-10.patch?id=c4256f68d3589570443075eccbbafacf661f785f";
-      sha256 = "sha256:0bpwrdfmi15grsg4jy7bzj2z6511a0c160cmw5lsi65aabyh7cl5";
-    }
-
-    # Add missing include required with recent Qt.
-    {
-      url = "https://gitlab.kitware.com/vtk/vtk/-/commit/797f28697d5ba50c1fa2bc5596af626a3c277826.diff";
-      sha256 = "BFjoKws1hVD3Ly9RS4lGN62J6RTyI1E8ATHrZdzg7ds=";
-    }
-  ];
-}
diff --git a/pkgs/development/libraries/vtk/generic.nix b/pkgs/development/libraries/vtk/generic.nix
index 467abeead3e3..b88ddee6b249 100644
--- a/pkgs/development/libraries/vtk/generic.nix
+++ b/pkgs/development/libraries/vtk/generic.nix
@@ -96,6 +96,6 @@ in stdenv.mkDerivation rec {
     maintainers = with maintainers; [ knedlsepp tfmoraes lheckemann ];
     platforms = with platforms; unix;
     # /nix/store/xxxxxxx-apple-framework-Security/Library/Frameworks/Security.framework/Headers/Authorization.h:192:7: error: variably modified 'bytes' at file scope
-    broken = stdenv.isDarwin && (lib.versions.major majorVersion == "7" || lib.versions.major majorVersion == "8");
+    broken = stdenv.isDarwin && (lib.versions.major majorVersion == "8");
   };
 }
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 3f5e0d176b73..60c7c2598a39 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -18873,15 +18873,16 @@ with pkgs;
     nodejs = nodejs-14_x;
   };
 
-  itk4 = callPackage ../development/libraries/itk/4.x.nix {
-    stdenv = if stdenv.cc.isGNU && stdenv.system == "x86_64-linux" then gcc10Stdenv else stdenv;
+  itk_5 = callPackage ../development/libraries/itk/5.x.nix {
     inherit (darwin.apple_sdk.frameworks) Cocoa;
   };
 
-  itk = callPackage ../development/libraries/itk {
+  itk-unstable = callPackage ../development/libraries/itk/unstable.nix {
     inherit (darwin.apple_sdk.frameworks) Cocoa;
   };
 
+  itk = itk_5;
+
   jama = callPackage ../development/libraries/jama { };
 
   jansson = callPackage ../development/libraries/jansson { };
@@ -21941,14 +21942,6 @@ with pkgs;
 
   vte_290 = callPackage ../development/libraries/vte/2.90.nix { };
 
-  vtk_7 = libsForQt515.callPackage ../development/libraries/vtk/7.x.nix {
-    stdenv = gcc9Stdenv;
-    inherit (darwin) libobjc;
-    inherit (darwin.apple_sdk.libs) xpc;
-    inherit (darwin.apple_sdk.frameworks) Cocoa CoreServices DiskArbitration
-                                          IOKit CFNetwork Security ApplicationServices
-                                          CoreText IOSurface ImageIO OpenGL GLUT;
-  };
   vtk_8 = libsForQt515.callPackage ../development/libraries/vtk/8.x.nix {
     stdenv = gcc9Stdenv;
     inherit (darwin) libobjc;
@@ -34033,7 +34026,6 @@ with pkgs;
   angsd = callPackage ../applications/science/biology/angsd { };
 
   ants = callPackage ../applications/science/biology/ants {
-    stdenv = if stdenv.cc.isGNU && stdenv.system == "x86_64-linux" then gcc10Stdenv else stdenv;
     inherit (darwin.apple_sdk.frameworks) Cocoa;
   };