diff --git a/pkgs/development/python-modules/pysimplegui/default.nix b/pkgs/development/python-modules/pysimplegui/default.nix
new file mode 100644
index 000000000000..9542ffe1b3bb
--- /dev/null
+++ b/pkgs/development/python-modules/pysimplegui/default.nix
@@ -0,0 +1,27 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+, tkinter
+}:
+buildPythonPackage rec {
+  pname = "PySimpleGUI";
+  version = "4.55.1";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "sha256-nUDAoMK0w9Luk1hU5I1yT1CK5oEj9LrIByYS3Z5wfew=";
+  };
+
+  pythonImportsCheck = [ "PySimpleGUI" ];
+
+  propagatedBuildInputs = [
+    tkinter
+  ];
+
+  meta = with lib; {
+    description = "Python GUIs for Humans.";
+    homepage = "https://github.com/PySimpleGUI/PySimpleGUI";
+    license = licenses.gpl3;
+    maintainers = with maintainers; [ lucasew ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index e44ce2f45e82..639e2b14eb43 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -7359,6 +7359,8 @@ in {
 
   pysigset = callPackage ../development/python-modules/pysigset { };
 
+  pysimplegui = callPackage ../development/python-modules/pysimplegui { };
+
   pysingleton = callPackage ../development/python-modules/pysingleton { };
 
   pyslurm = callPackage ../development/python-modules/pyslurm {