diff --git a/pkgs/development/python-modules/sciline/default.nix b/pkgs/development/python-modules/sciline/default.nix
new file mode 100644
index 000000000000..f9f58da4b938
--- /dev/null
+++ b/pkgs/development/python-modules/sciline/default.nix
@@ -0,0 +1,70 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+
+  # build-system
+  setuptools,
+  setuptools-scm,
+
+  # dependencies
+  cyclebane,
+
+  # tests
+  pytestCheckHook,
+  pytest-randomly,
+  rich,
+  dask,
+  graphviz,
+  jsonschema,
+  numpy,
+  pandas,
+  pydantic,
+}:
+
+buildPythonPackage (finalAttrs: {
+  pname = "sciline";
+  version = "25.11.1";
+  pyproject = true;
+  __structuredAttrs = true;
+
+  src = fetchFromGitHub {
+    owner = "scipp";
+    repo = "sciline";
+    tag = finalAttrs.version;
+    hash = "sha256-BTdvPAeI7SWV8gNfXVC63YKghZOfJ9eFousOqycpTAw=";
+  };
+
+  build-system = [
+    setuptools
+    setuptools-scm
+  ];
+
+  dependencies = [
+    cyclebane
+  ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+    pytest-randomly
+    dask
+    graphviz
+    jsonschema
+    numpy
+    pandas
+    pydantic
+    rich
+  ];
+
+  pythonImportsCheck = [
+    "sciline"
+  ];
+
+  meta = {
+    description = "Build scientific pipelines for your data";
+    homepage = "https://scipp.github.io/sciline/";
+    changelog = "https://github.com/scipp/sciline/releases/tag/${finalAttrs.src.tag}";
+    license = lib.licenses.bsd3;
+    maintainers = with lib.maintainers; [ doronbehar ];
+  };
+})
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 8555929304d9..ba5605e313da 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -17768,6 +17768,8 @@ self: super: with self; {
 
   scikits-odes-sundials = callPackage ../development/python-modules/scikits-odes-sundials { };
 
+  sciline = callPackage ../development/python-modules/sciline { };
+
   scim2-client = callPackage ../development/python-modules/scim2-client { };
 
   scim2-filter-parser = callPackage ../development/python-modules/scim2-filter-parser { };