diff --git a/pkgs/development/python-modules/pyschemes/default.nix b/pkgs/development/python-modules/pyschemes/default.nix
index c7034d11cdca..3b7eaa0da421 100644
--- a/pkgs/development/python-modules/pyschemes/default.nix
+++ b/pkgs/development/python-modules/pyschemes/default.nix
@@ -1,8 +1,8 @@
 { lib
 , buildPythonPackage
 , fetchFromGitHub
-, pythonAtLeast
 , pytestCheckHook
+, fetchpatch
 }:
 
 buildPythonPackage rec {
@@ -10,8 +10,6 @@ buildPythonPackage rec {
   version = "unstable-2017-11-08";
   format = "setuptools";
 
-  disabled = pythonAtLeast "3.10";
-
   src = fetchFromGitHub {
     owner = "spy16";
     repo = pname;
@@ -19,6 +17,14 @@ buildPythonPackage rec {
     hash = "sha256-PssucudvlE8mztwVme70+h+2hRW/ri9oV9IZayiZhdU=";
   };
 
+  patches = [
+    # Fix python 3.10 compatibility. Tracked upstream in
+    # https://github.com/spy16/pyschemes/pull/6
+    (fetchpatch {
+      url = "https://github.com/spy16/pyschemes/commit/23011128c6c22838d4fca9e00fd322a20bb566c4.patch";
+      sha256 = "sha256-vDaWxMrn2aC2wmd035EWRZ3cd/XME81z/BWG0f2T9jc=";
+    })
+  ];
   checkInputs = [
     pytestCheckHook
   ];