diff --git a/pkgs/development/python-modules/gpy/default.nix b/pkgs/development/python-modules/gpy/default.nix
deleted file mode 100644
index b08291c3c878..000000000000
--- a/pkgs/development/python-modules/gpy/default.nix
+++ /dev/null
@@ -1,68 +0,0 @@
-{
-  lib,
-  stdenv,
-  buildPythonPackage,
-  fetchFromGitHub,
-  pythonOlder,
-  pytestCheckHook,
-  setuptools,
-  numpy,
-  scipy,
-  six,
-  paramz,
-  matplotlib,
-  cython,
-}:
-
-buildPythonPackage rec {
-  pname = "gpy";
-  version = "1.13.2";
-  pyproject = true;
-
-  disabled = pythonOlder "3.9";
-
-  src = fetchFromGitHub {
-    owner = "SheffieldML";
-    repo = "GPy";
-    tag = "v${version}";
-    hash = "sha256-kggXePDKJcgw8qwLIBTxbwhiLw2H4dkx7082FguKP0Y=";
-  };
-
-  pythonRelaxDeps = [
-    "paramz"
-    "scipy"
-  ];
-
-  nativeBuildInputs = [ setuptools ];
-  buildInputs = [ cython ];
-  propagatedBuildInputs = [
-    numpy
-    scipy
-    six
-    paramz
-    matplotlib
-  ];
-  nativeCheckInputs = [ pytestCheckHook ];
-
-  # Rebuild cython-generated .c files to ensure compatibility
-  preBuild = ''
-    for fn in $(find . -name '*.pyx'); do
-      echo $fn | sed 's/\.\.pyx$/\.c/' | xargs ${cython}/bin/cython -3
-    done
-  '';
-
-  disabledTests = lib.optionals (stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isx86_64) [
-    # Rounding difference break comparison
-    "TestGradientMultiOutputGPModel"
-  ];
-
-  pythonImportsCheck = [ "GPy" ];
-
-  meta = with lib; {
-    description = "Gaussian process framework in Python";
-    homepage = "https://sheffieldml.github.io/GPy";
-    changelog = "https://github.com/SheffieldML/GPy/releases/tag/v${version}";
-    license = licenses.bsd3;
-    maintainers = with maintainers; [ bcdarwin ];
-  };
-}
diff --git a/pkgs/development/python-modules/paramz/default.nix b/pkgs/development/python-modules/paramz/default.nix
deleted file mode 100644
index 7f2bd1a38fad..000000000000
--- a/pkgs/development/python-modules/paramz/default.nix
+++ /dev/null
@@ -1,73 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  decorator,
-  fetchFromGitHub,
-  numpy,
-  pytestCheckHook,
-  pythonOlder,
-  scipy,
-  setuptools,
-  six,
-}:
-
-buildPythonPackage rec {
-  pname = "paramz";
-  version = "0.9.6";
-  pyproject = true;
-
-  disabled = pythonOlder "3.7";
-
-  src = fetchFromGitHub {
-    owner = "sods";
-    repo = "paramz";
-    tag = "v${version}";
-    hash = "sha256-SWmx70G5mm3eUmH2UIEmg5C7u9VDHiFw5aYCIr8UjPs=";
-  };
-
-  build-system = [ setuptools ];
-
-  dependencies = [
-    decorator
-    numpy
-    scipy
-    six
-  ];
-
-  nativeCheckInputs = [ pytestCheckHook ];
-
-  preCheck = ''
-    substituteInPlace paramz/tests/parameterized_tests.py \
-      --replace-fail "assertRaisesRegexp" "assertRaisesRegex"
-  '';
-
-  enabledTestPaths = [
-    "paramz/tests/array_core_tests.py"
-    "paramz/tests/cacher_tests.py"
-    "paramz/tests/examples_tests.py"
-    "paramz/tests/index_operations_tests.py"
-    "paramz/tests/init_tests.py"
-    "paramz/tests/lists_and_dicts_tests.py"
-    "paramz/tests/model_tests.py"
-    "paramz/tests/observable_tests.py"
-    "paramz/tests/parameterized_tests.py"
-    "paramz/tests/pickle_tests.py"
-    "paramz/tests/verbose_optimize_tests.py"
-  ];
-
-  disabledTests = [
-    # TypeError: arrays to stack must be passed as a "sequence" type such as list...
-    "test_raveled_index"
-    "test_regular_expression_misc"
-  ];
-
-  pythonImportsCheck = [ "paramz" ];
-
-  meta = with lib; {
-    description = "Parameterization framework for parameterized model creation and handling";
-    homepage = "https://github.com/sods/paramz";
-    changelog = "https://github.com/sods/paramz/releases/tag/v${version}";
-    license = licenses.bsd3;
-    maintainers = with maintainers; [ bcdarwin ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 7a6432e7b08e..fcf56ad7af20 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -186,6 +186,7 @@ mapAliases {
   googleapis_common_protos = throw "'googleapis_common_protos' has been renamed to/replaced by 'googleapis-common-protos'"; # Converted to throw 2025-10-29
   gpapi = throw "'gpapi' has been superseded by google-api-python-client"; # Added 2025-11-09
   gplaycli = throw "'gplaycli' has been removed as it was broken and lacked maintenance"; # Added 2025-11-09
+  gpy = throw "'gpy' has been removed as it is based on 'paramz', which was removed"; # added 2025-11-10
   gradient_statsd = throw "'gradient_statsd' has been renamed to/replaced by 'gradient-statsd'"; # Converted to throw 2025-10-29
   grappelli_safe = throw "'grappelli_safe' has been renamed to/replaced by 'grappelli-safe'"; # Converted to throw 2025-10-29
   groestlcoin_hash = throw "'groestlcoin_hash' has been renamed to/replaced by 'groestlcoin-hash'"; # Converted to throw 2025-10-29
@@ -287,6 +288,7 @@ mapAliases {
   orm = throw "orm has been removed as it is unmaintained"; # added 2025-08-27
   paho-mqtt_2 = throw "'paho-mqtt_2' has been renamed to/replaced by 'paho-mqtt'"; # Converted to throw 2025-10-29
   pam = throw "'pam' has been renamed to/replaced by 'python-pam'"; # Converted to throw 2025-10-29
+  paramz = throw "'paramz' has been removed as it is incompatible with Numpy 2"; # added 2025-11-10
   PasteDeploy = throw "'PasteDeploy' has been renamed to/replaced by 'pastedeploy'"; # Converted to throw 2025-10-29
   pathpy = throw "'pathpy' has been renamed to/replaced by 'path'"; # Converted to throw 2025-10-29
   pcbnew-transition = throw "'pcbnew-transition' has been renamed to/replaced by 'pcbnewtransition'"; # Converted to throw 2025-10-29
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index eb82560f6b42..ad746cdf7611 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -6328,8 +6328,6 @@ self: super: with self; {
 
   gpxpy = callPackage ../development/python-modules/gpxpy { };
 
-  gpy = callPackage ../development/python-modules/gpy { };
-
   gpytorch = callPackage ../development/python-modules/gpytorch { };
 
   gql = callPackage ../development/python-modules/gql { };
@@ -11584,8 +11582,6 @@ self: super: with self; {
 
   paramiko = callPackage ../development/python-modules/paramiko { };
 
-  paramz = callPackage ../development/python-modules/paramz { };
-
   paranoid-crypto = callPackage ../development/python-modules/paranoid-crypto { };
 
   parfive = callPackage ../development/python-modules/parfive { };