diff --git a/pkgs/development/python-modules/tpm2-pytss/cross.patch b/pkgs/development/python-modules/tpm2-pytss/cross.patch
index 8fa2956c11d0..444323e28197 100644
--- a/pkgs/development/python-modules/tpm2-pytss/cross.patch
+++ b/pkgs/development/python-modules/tpm2-pytss/cross.patch
@@ -2,21 +2,19 @@ diff --git a/setup.py b/setup.py
 index 1b5f513..d660b9a 100644
 --- a/setup.py
 +++ b/setup.py
-@@ -184,7 +184,8 @@ class type_generator(build_ext):
-                 f"unable to find tss2_tpm2_types.h in {pk['include_dirs']}"
+@@ -199,6 +199,7 @@
+             pdata = preprocess_file(
+                 header_path,
+                 cpp_args=["-std=c99", "-D__extension__=", "-D__attribute__(x)="],
++                cpp_path="@crossPrefix@-cpp",
              )
-         pdata = preprocess_file(
--            header_path, cpp_args=["-D__extension__=", "-D__attribute__(x)="]
-+            header_path, cpp_args=["-D__extension__=", "-D__attribute__(x)="],
-+            cpp_path="@crossPrefix@-cpp",
-         )
          parser = c_parser.CParser()
          ast = parser.parse(pdata, "tss2_tpm2_types.h")
-@@ -210,6 +211,7 @@ class type_generator(build_ext):
-                         "-D__float128=long double",
-                         "-D_FORTIFY_SOURCE=0",
-                     ],
-+                    cpp_path="@crossPrefix@-cpp",
-                 )
+@@ -238,6 +239,7 @@
+                             "-D__float128=long double",
+                             "-D_FORTIFY_SOURCE=0",
+                         ],
++                        cpp_path="@crossPrefix@-cpp",
+                     )
                  parser = c_parser.CParser()
                  past = parser.parse(pdata, "tss2_policy.h")
diff --git a/pkgs/development/python-modules/tpm2-pytss/default.nix b/pkgs/development/python-modules/tpm2-pytss/default.nix
index 235b4688470d..dbefc00be8c3 100644
--- a/pkgs/development/python-modules/tpm2-pytss/default.nix
+++ b/pkgs/development/python-modules/tpm2-pytss/default.nix
@@ -70,6 +70,7 @@ buildPythonPackage rec {
     # when cross-compiling is turned on.
     # This patch changes the call to pycparser.preprocess_file to provide the name
     # of the cross-compiling cpp
+    # NOTE: This patch could be dropped after next release. 3.0.0-rc0 already have proper `$CC -E` invocation
     (replaceVars ./cross.patch {
       crossPrefix = stdenv.hostPlatform.config;
     })