diff --git a/pkgs/applications/virtualization/qemu/default.nix b/pkgs/applications/virtualization/qemu/default.nix
index 7c9d5c30312a..68399723ade7 100644
--- a/pkgs/applications/virtualization/qemu/default.nix
+++ b/pkgs/applications/virtualization/qemu/default.nix
@@ -33,8 +33,6 @@
   libslirp,
   apple-sdk_13,
   darwinMinVersionHook,
-  rez,
-  setfile,
   guestAgentSupport ?
     (with stdenv.hostPlatform; isLinux || isNetBSD || isOpenBSD || isSunOS || isWindows) && !minimal,
   numaSupport ? stdenv.hostPlatform.isLinux && !stdenv.hostPlatform.isAarch32 && !minimal,
@@ -179,8 +177,6 @@ stdenv.mkDerivation (finalAttrs: {
     ++ lib.optionals hexagonSupport [ glib ]
     ++ lib.optionals stdenv.hostPlatform.isDarwin [
       sigtool
-      rez
-      setfile
     ]
     ++ lib.optionals (!userOnly) [ dtc ];
 
@@ -263,6 +259,13 @@ stdenv.mkDerivation (finalAttrs: {
   patches = [
     ./fix-qemu-ga.patch
 
+    # On macOS, QEMU uses `Rez(1)` and `SetFile(1)` to attach its icon
+    # to the binary. Unfortunately, those commands are proprietary,
+    # deprecated since Xcode 6, and operate on resource forks, which
+    # these days are stored in extended attributes, which aren’t
+    # supported in the Nix store. So we patch out the calls.
+    ./skip-macos-icon.patch
+
     # Workaround for upstream issue with nested virtualisation: https://gitlab.com/qemu-project/qemu/-/issues/1008
     (fetchpatch {
       url = "https://gitlab.com/qemu-project/qemu/-/commit/3e4546d5bd38a1e98d4bd2de48631abf0398a3a2.diff";
diff --git a/pkgs/applications/virtualization/qemu/skip-macos-icon.patch b/pkgs/applications/virtualization/qemu/skip-macos-icon.patch
new file mode 100644
index 000000000000..4f6f3a9a9e4a
--- /dev/null
+++ b/pkgs/applications/virtualization/qemu/skip-macos-icon.patch
@@ -0,0 +1,14 @@
+diff --git a/scripts/entitlement.sh b/scripts/entitlement.sh
+index 0f412949ec..23f56d083a 100755
+--- a/scripts/entitlement.sh
++++ b/scripts/entitlement.sh
+@@ -25,9 +25,5 @@
+   codesign --entitlements "$ENTITLEMENT" --force -s - "$SRC"
+ fi
+ 
+-# Add the QEMU icon to the binary on Mac OS
+-Rez -append "$ICON" -o "$SRC"
+-SetFile -a C "$SRC"
+-
+ mv -f "$SRC" "$DST"
+ trap '' exit
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 707126c1a872..f90e43fdee32 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -14735,7 +14735,6 @@ with pkgs;
   eiskaltdcpp = libsForQt5.callPackage ../applications/networking/p2p/eiskaltdcpp { };
 
   qemu = callPackage ../applications/virtualization/qemu {
-    inherit (darwin.stubs) rez setfile;
     inherit (darwin) sigtool;
   };