diff --git a/pkgs/applications/networking/mailreaders/notmuch/default.nix b/pkgs/applications/networking/mailreaders/notmuch/default.nix
index 54403b0ea321..df945098ef7b 100644
--- a/pkgs/applications/networking/mailreaders/notmuch/default.nix
+++ b/pkgs/applications/networking/mailreaders/notmuch/default.nix
@@ -79,6 +79,16 @@ stdenv.mkDerivation (finalAttrs: {
     substituteInPlace emacs/notmuch-emacs-mua \
       --replace 'EMACS:-emacs' 'EMACS:-${emacs}/bin/emacs' \
       --replace 'EMACSCLIENT:-emacsclient' 'EMACSCLIENT:-${emacs}/bin/emacsclient'
+  ''
+  + lib.optionalString stdenv.hostPlatform.isDarwin ''
+    # The configure script runs the minimal test program
+    # when checking support for address and thread sanitizer (asan and tsan).
+    # On Darwin the minimal test program hangs when compiled
+    # with the asan and tsan compile options.
+    # Since asan and tsan are supported on Darwin the runtime
+    # check is skipped as follows:
+    substituteInPlace configure \
+      --replace './minimal' 'true'
   '';
 
   configureFlags = [