diff --git a/pkgs/development/python-modules/biopython/default.nix b/pkgs/development/python-modules/biopython/default.nix
index 8412314ae211..d2d56fded6ce 100644
--- a/pkgs/development/python-modules/biopython/default.nix
+++ b/pkgs/development/python-modules/biopython/default.nix
@@ -33,6 +33,8 @@ buildPythonPackage rec {
   '';
 
   meta = {
+    # https://github.com/biopython/biopython/issues/5135
+    broken = lib.versionAtLeast numpy.version "2.4";
     description = "Python library for bioinformatics";
     longDescription = ''
       Biopython is a set of freely available tools for biological computation