diff --git a/pkgs/by-name/pd/pdftitle/package.nix b/pkgs/by-name/pd/pdftitle/package.nix
index d28ca7f8e281..2e402c91cb3f 100644
--- a/pkgs/by-name/pd/pdftitle/package.nix
+++ b/pkgs/by-name/pd/pdftitle/package.nix
@@ -2,7 +2,6 @@
   lib,
   fetchFromGitHub,
   python3Packages,
-  openai,
   pdfminer,
 
   withOpenai ? false,
diff --git a/pkgs/development/python-modules/openai/default.nix b/pkgs/development/python-modules/openai/default.nix
index ddfa0f3b8548..41871cd05921 100644
--- a/pkgs/development/python-modules/openai/default.nix
+++ b/pkgs/development/python-modules/openai/default.nix
@@ -51,14 +51,14 @@
 
 buildPythonPackage rec {
   pname = "openai";
-  version = "2.33.0";
+  version = "2.41.1";
   pyproject = true;
 
   src = fetchFromGitHub {
     owner = "openai";
     repo = "openai-python";
     tag = "v${version}";
-    hash = "sha256-w2ejAJ+V7e4wYSQ/9+WdhO+XaYeSq8U/V5YXHSpn+rI=";
+    hash = "sha256-jSkBxZY5POlrznhBwFMR2NcL92uGRSYI6BDDC3C7RfU=";
   };
 
   postPatch = ''substituteInPlace pyproject.toml --replace-fail "hatchling==1.26.3" "hatchling"'';
@@ -129,6 +129,5 @@ buildPythonPackage rec {
     changelog = "https://github.com/openai/openai-python/blob/${src.tag}/CHANGELOG.md";
     license = lib.licenses.asl20;
     maintainers = [ lib.maintainers.malo ];
-    mainProgram = "openai";
   };
 }
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index 19b65f801709..9879901db688 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -1682,6 +1682,7 @@ mapAliases {
   open-stage-control = throw "'open-stage-control' has been removed due to being broken for more than a year; see RFC 180"; # Added 2026-05-04
   open-timeline-io = warnAlias "'open-timeline-io' has been renamed to 'opentimelineio'" opentimelineio; # Added 2025-08-10
   openafs_1_8 = throw "'openafs_1_8' has been renamed to/replaced by 'openafs'"; # Converted to throw 2025-10-27
+  openai = throw "'openai' has been removed, since upstream removed the legacy CLI in v2.35.0; use 'python3Packages.openai' instead"; # Added 2026-06-10
   openai-triton-llvm = throw "'openai-triton-llvm' has been renamed to/replaced by 'triton-llvm'"; # Converted to throw 2025-10-27
   openai-whisper-cpp = throw "'openai-whisper-cpp' has been renamed to/replaced by 'whisper-cpp'"; # Converted to throw 2025-10-27
   openalSoft = warnAlias "'openalSoft' has been renamed to 'openal-soft'" openal-soft; # Added 2026-02-09
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 748f61a2ba44..e1f46c269394 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -5325,8 +5325,6 @@ with pkgs;
     sdk = true;
   };
 
-  openai = with python3Packages; toPythonApplication openai;
-
   openai-whisper = with python3.pkgs; toPythonApplication openai-whisper;
 
   oprofile = callPackage ../development/tools/profiling/oprofile {