diff --git a/nixos/modules/system/activation/nixos-init.nix b/nixos/modules/system/activation/nixos-init.nix
index 5fc2f1bf0e07..a2928cf1e0a1 100644
--- a/nixos/modules/system/activation/nixos-init.nix
+++ b/nixos/modules/system/activation/nixos-init.nix
@@ -34,6 +34,14 @@ in
         assertion = config.services.userborn.enable || config.systemd.sysusers.enable;
         message = "nixos-init can only be used with services.userborn.enable or systemd.sysusers.enable";
       }
+      {
+        assertion = config.boot.postBootCommands == "";
+        message = "nixos-init cannot be used with boot.postBootCommands";
+      }
+      {
+        assertion = config.powerManagement.powerUpCommands == "";
+        message = "nixos-init cannot be used with powerManagement.powerUpCommands";
+      }
     ];
   };
 }
diff --git a/nixos/tests/activation/nixos-init.nix b/nixos/tests/activation/nixos-init.nix
index 0635efba28b8..2b3ee5c5ec55 100644
--- a/nixos/tests/activation/nixos-init.nix
+++ b/nixos/tests/activation/nixos-init.nix
@@ -11,6 +11,7 @@
       boot.initrd.systemd.enable = true;
       system.etc.overlay.enable = true;
       services.userborn.enable = true;
+      boot.postBootCommands = lib.mkForce "";
 
       system.nixos-init.enable = true;
       # Forcibly set this to only these specific values.