diff --git a/pkgs/applications/video/mpv/default.nix b/pkgs/applications/video/mpv/default.nix
index cf81c0e0446c..beb6c70f4eea 100644
--- a/pkgs/applications/video/mpv/default.nix
+++ b/pkgs/applications/video/mpv/default.nix
@@ -24,6 +24,7 @@
 , waylandSupport ? stdenv.isLinux
   , wayland
   , wayland-protocols
+  , wayland-scanner
   , libxkbcommon
 
 , x11Support ? stdenv.isLinux
@@ -100,6 +101,10 @@ in stdenv.mkDerivation rec {
   NIX_LDFLAGS = lib.optionalString x11Support "-lX11 -lXext "
     + lib.optionalString stdenv.isDarwin "-framework CoreFoundation";
 
+  # These flags are not supported and cause the build
+  # to fail, even when cross compilation itself works.
+  dontAddWafCrossFlags = true;
+
   wafConfigureFlags = [
     "--enable-libmpv-shared"
     "--enable-manpage-build"
@@ -127,7 +132,8 @@ in stdenv.mkDerivation rec {
     python3
     wafHook
     which
-  ] ++ lib.optionals swiftSupport [ swift ];
+  ] ++ lib.optionals swiftSupport   [ swift ]
+    ++ lib.optionals waylandSupport [ wayland-scanner ];
 
   buildInputs = [
     ffmpeg
diff --git a/pkgs/development/python-modules/setuptools/default.nix b/pkgs/development/python-modules/setuptools/default.nix
index 883ca18e93e4..2d3c06d602f1 100644
--- a/pkgs/development/python-modules/setuptools/default.nix
+++ b/pkgs/development/python-modules/setuptools/default.nix
@@ -1,6 +1,7 @@
 { stdenv
 , buildPythonPackage
 , fetchFromGitHub
+, fetchpatch
 , python
 , bootstrapped-pip
 , lib
@@ -27,6 +28,14 @@ let
     patches = [
       ./tag-date.patch
       ./setuptools-distutils-C++.patch
+      # Fix cross compilation of extension modules
+      # https://github.com/pypa/distutils/pull/173
+      (fetchpatch {
+        url = "https://github.com/pypa/distutils/commit/22b9bcf2e2d2a66f7dc96661312972e2f6bd9e01.patch";
+        hash = "sha256-IVb1LLgLIHO6HPn2911uksrLB1jG0MyQetdxkq5wcG4=";
+        stripLen = 2;
+        extraPrefix = "setuptools/_distutils/";
+      })
     ];
 
     buildPhase = ''