diff --git a/pkgs/development/python-modules/grpcio-tools/default.nix b/pkgs/development/python-modules/grpcio-tools/default.nix
index d386deb44221..6d8b370e9032 100644
--- a/pkgs/development/python-modules/grpcio-tools/default.nix
+++ b/pkgs/development/python-modules/grpcio-tools/default.nix
@@ -2,16 +2,16 @@
 
 buildPythonPackage rec {
   pname = "grpcio-tools";
-  version = "1.48.1";
+  version = "1.49.1";
 
   src = fetchPypi {
     inherit pname version;
-    sha256 = "1178f2ea531f80cc2027ec64728df6ffc8e98cf1df61652a496eafd612127183";
+    sha256 = "sha256-hMxk5bRrrUPV170v13K2VuugNmlhGHqEfpCOLLc125E=";
   };
 
   postPatch = ''
     substituteInPlace setup.py \
-    --replace 'protobuf>=3.12.0, < 4.0dev' 'protobuf'
+      --replace 'protobuf>=4.21.3,<5.0dev' 'protobuf'
   '';
 
   outputs = [ "out" "dev" ];