diff --git a/pkgs/development/python-modules/h5py/default.nix b/pkgs/development/python-modules/h5py/default.nix
index 192fe6d7158b..26b2a38984ed 100644
--- a/pkgs/development/python-modules/h5py/default.nix
+++ b/pkgs/development/python-modules/h5py/default.nix
@@ -35,20 +35,19 @@ buildPythonPackage rec {
 
   pythonRelaxDeps = [ "mpi4py" ];
 
-  # avoid strict pinning of numpy and mpi4py, can't be replaced with
-  # pythonRelaxDepsHook, see: https://github.com/NixOS/nixpkgs/issues/327941
+  # Avoid strict pinning of Numpy, can't be replaced with pythonRelaxDepsHook,
+  # as these are build time dependencies. See:
+  # https://github.com/NixOS/nixpkgs/issues/327941
   postPatch = ''
     substituteInPlace pyproject.toml \
       --replace-fail "numpy >=2.0.0, <3" "numpy"
-    substituteInPlace setup.py \
-      --replace-fail "mpi4py ==3.1.4" "mpi4py" \
-      --replace-fail "mpi4py ==4.0.1" "mpi4py" \
-      --replace-fail "mpi4py ==3.1.6" "mpi4py"
   '';
 
   env = {
     HDF5_DIR = "${hdf5}";
     HDF5_MPI = if mpiSupport then "ON" else "OFF";
+    # See discussion at https://github.com/h5py/h5py/issues/2560
+    H5PY_SETUP_REQUIRES = 0;
   };
 
   postConfigure = ''