diff --git a/pkgs/development/python-modules/python-jenkins/default.nix b/pkgs/development/python-modules/python-jenkins/default.nix
index 863ab45ed548..7c1f8e720f5b 100644
--- a/pkgs/development/python-modules/python-jenkins/default.nix
+++ b/pkgs/development/python-modules/python-jenkins/default.nix
@@ -35,7 +35,10 @@ buildPythonPackage rec {
 
    nativeCheckInputs = [ stestr testscenarios requests-mock ];
    checkPhase = ''
-     stestr run
+     # Skip tests that fail due to setuptools>=66.0.0 rejecting PEP 440
+     # non-conforming versions. See
+     # https://github.com/pypa/setuptools/issues/2497 for details.
+     stestr run -E "tests.test_plugins.(PluginsTestScenarios.test_plugin_version_comparison|PluginsTestScenarios.test_plugin_version_object_comparison|PluginsTest.test_plugin_equal|PluginsTest.test_plugin_not_equal)"
    '';
 
   meta = with lib; {