diff --git a/pkgs/by-name/uv/uv/Cargo.lock b/pkgs/by-name/uv/uv/Cargo.lock
index 18313bd9b952..318301d86d6d 100644
--- a/pkgs/by-name/uv/uv/Cargo.lock
+++ b/pkgs/by-name/uv/uv/Cargo.lock
@@ -684,9 +684,9 @@ dependencies = [
 
 [[package]]
 name = "clap"
-version = "4.5.7"
+version = "4.5.8"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "5db83dced34638ad474f39f250d7fea9598bdd239eaced1bdf45d597da0f433f"
+checksum = "84b3edb18336f4df585bc9aa31dd99c036dfa5dc5e9a2939a722a188f3a8970d"
 dependencies = [
  "clap_builder",
  "clap_derive",
@@ -694,9 +694,9 @@ dependencies = [
 
 [[package]]
 name = "clap_builder"
-version = "4.5.7"
+version = "4.5.8"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f7e204572485eb3fbf28f871612191521df159bc3e15a9f5064c66dba3a8c05f"
+checksum = "c1c09dd5ada6c6c78075d6fd0da3f90d8080651e2d6cc8eb2f1aaa4034ced708"
 dependencies = [
  "anstream",
  "anstyle",
@@ -748,9 +748,9 @@ dependencies = [
 
 [[package]]
 name = "clap_derive"
-version = "4.5.5"
+version = "4.5.8"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "c780290ccf4fb26629baa7a1081e68ced113f1d3ec302fa5948f1c381ebf06c6"
+checksum = "2bac35c6dafb060fd4d275d9a4ffae97917c13a6327903a8be2153cd964f7085"
 dependencies = [
  "heck 0.5.0",
  "proc-macro2",
@@ -989,11 +989,12 @@ dependencies = [
 
 [[package]]
 name = "dashmap"
-version = "5.5.3"
+version = "6.0.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "978747c1d849a7d2ee5e8adc0159961c48fb7e5db2f06af6723b80123bb53856"
+checksum = "804c8821570c3f8b70230c2ba75ffa5c0f9a4189b9a432b6656c536712acae28"
 dependencies = [
  "cfg-if",
+ "crossbeam-utils",
  "hashbrown 0.14.5",
  "lock_api",
  "once_cell",
@@ -1145,9 +1146,9 @@ checksum = "0d6ef0072f8a535281e4876be788938b528e9a1d43900b82c2569af7da799125"
 
 [[package]]
 name = "either"
-version = "1.12.0"
+version = "1.13.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "3dca9240753cf90908d7e4aac30f630662b02aebaa1b58a3cadabdb23385b58b"
+checksum = "60b1af1c220855b6ceac025d3f6ecdd2b7c4894bfe9cd9bda4fbb4bc7c0d4cf0"
 
 [[package]]
 name = "encode_unicode"
@@ -2073,9 +2074,9 @@ dependencies = [
 
 [[package]]
 name = "memchr"
-version = "2.7.2"
+version = "2.7.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "6c8640c5d730cb13ebd907d8d04b52f55ac9a2eec55b440c8892f40d56c76c1d"
+checksum = "78ca9ab1a0babb1e7d5695e3530886289c18cf2f87ec19a575a0abdce112e3a3"
 
 [[package]]
 name = "memmap2"
@@ -2715,7 +2716,7 @@ dependencies = [
  "indoc",
  "libc",
  "memoffset 0.9.1",
- "parking_lot 0.12.3",
+ "parking_lot 0.11.2",
  "portable-atomic",
  "pyo3-build-config",
  "pyo3-ffi",
@@ -3116,9 +3117,8 @@ dependencies = [
 
 [[package]]
 name = "reqwest-middleware"
-version = "0.3.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a45d100244a467870f6cb763c4484d010a6bed6bd610b3676e3825d93fb4cfbd"
+version = "0.3.2"
+source = "git+https://github.com/astral-sh/reqwest-middleware?rev=21ceec9a5fd2e8d6f71c3ea2999078fecbd13cbe#21ceec9a5fd2e8d6f71c3ea2999078fecbd13cbe"
 dependencies = [
  "anyhow",
  "async-trait",
@@ -3131,9 +3131,8 @@ dependencies = [
 
 [[package]]
 name = "reqwest-retry"
-version = "0.5.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "40f342894422862af74c50e1e9601cf0931accc9c6981e5eb413c46603b616b5"
+version = "0.7.0"
+source = "git+https://github.com/astral-sh/reqwest-middleware?rev=21ceec9a5fd2e8d6f71c3ea2999078fecbd13cbe#21ceec9a5fd2e8d6f71c3ea2999078fecbd13cbe"
 dependencies = [
  "anyhow",
  "async-trait",
@@ -3146,6 +3145,7 @@ dependencies = [
  "reqwest",
  "reqwest-middleware",
  "retry-policies",
+ "thiserror",
  "tokio",
  "tracing",
  "wasm-timer",
@@ -3172,12 +3172,10 @@ dependencies = [
 
 [[package]]
 name = "retry-policies"
-version = "0.3.0"
+version = "0.4.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "493b4243e32d6eedd29f9a398896e35c6943a123b55eec97dcaee98310d25810"
+checksum = "5875471e6cab2871bc150ecb8c727db5113c9338cc3354dc5ee3425b6aa40a1c"
 dependencies = [
- "anyhow",
- "chrono",
  "rand",
 ]
 
@@ -3517,9 +3515,9 @@ dependencies = [
 
 [[package]]
 name = "serde_json"
-version = "1.0.117"
+version = "1.0.119"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "455182ea6142b14f93f4bc5320a2b31c1f266b66a4a5c858b013302a5d8cbfc3"
+checksum = "e8eddb61f0697cc3989c5d64b452f5488e2b8a60fd7d5076a3045076ffef8cb0"
 dependencies = [
  "itoa",
  "ryu",
@@ -4427,7 +4425,7 @@ checksum = "a183cf7feeba97b4dd1c0d46788634f6221d87fa961b305bed08c851829efcc0"
 
 [[package]]
 name = "uv"
-version = "0.2.15"
+version = "0.2.21"
 dependencies = [
  "anstream",
  "anyhow",
@@ -4487,7 +4485,9 @@ dependencies = [
  "uv-normalize",
  "uv-requirements",
  "uv-resolver",
+ "uv-scripts",
  "uv-settings",
+ "uv-tool",
  "uv-toolchain",
  "uv-types",
  "uv-virtualenv",
@@ -4737,6 +4737,7 @@ dependencies = [
  "anyhow",
  "distribution-filename",
  "distribution-types",
+ "either",
  "fs-err",
  "futures",
  "glob",
@@ -4829,6 +4830,7 @@ dependencies = [
  "dashmap",
  "fs-err",
  "reqwest",
+ "reqwest-middleware",
  "thiserror",
  "tokio",
  "tracing",
@@ -4977,6 +4979,22 @@ dependencies = [
  "uv-warnings",
 ]
 
+[[package]]
+name = "uv-scripts"
+version = "0.0.1"
+dependencies = [
+ "fs-err",
+ "indoc",
+ "memchr",
+ "once_cell",
+ "pep440_rs",
+ "pep508_rs",
+ "pypi-types",
+ "serde",
+ "thiserror",
+ "toml",
+]
+
 [[package]]
 name = "uv-settings"
 version = "0.0.1"
@@ -4998,6 +5016,7 @@ dependencies = [
  "uv-normalize",
  "uv-resolver",
  "uv-toolchain",
+ "uv-warnings",
 ]
 
 [[package]]
@@ -5009,6 +5028,31 @@ dependencies = [
  "tempfile",
 ]
 
+[[package]]
+name = "uv-tool"
+version = "0.0.1"
+dependencies = [
+ "dirs-sys",
+ "fs-err",
+ "install-wheel-rs",
+ "path-slash",
+ "pathdiff",
+ "pep440_rs",
+ "pep508_rs",
+ "pypi-types",
+ "serde",
+ "thiserror",
+ "toml",
+ "toml_edit",
+ "tracing",
+ "uv-cache",
+ "uv-fs",
+ "uv-state",
+ "uv-toolchain",
+ "uv-virtualenv",
+ "uv-warnings",
+]
+
 [[package]]
 name = "uv-toolchain"
 version = "0.0.1"
@@ -5077,7 +5121,7 @@ dependencies = [
 
 [[package]]
 name = "uv-version"
-version = "0.2.15"
+version = "0.2.21"
 
 [[package]]
 name = "uv-virtualenv"
diff --git a/pkgs/by-name/uv/uv/package.nix b/pkgs/by-name/uv/uv/package.nix
index 8590c1bee0e5..7fea5ed0a55e 100644
--- a/pkgs/by-name/uv/uv/package.nix
+++ b/pkgs/by-name/uv/uv/package.nix
@@ -4,7 +4,6 @@
 , fetchFromGitHub
 , installShellFiles
 , libiconv
-, openssl
 , pkg-config
 , python3Packages
 , rustPlatform
@@ -16,14 +15,14 @@
 
 python3Packages.buildPythonApplication rec {
   pname = "uv";
-  version = "0.2.15";
+  version = "0.2.21";
   pyproject = true;
 
   src = fetchFromGitHub {
     owner = "astral-sh";
     repo = "uv";
     rev = "refs/tags/${version}";
-    hash = "sha256-dHw08huVslrePcZvIXhui87bPGp5+CChiN+DtY7bLVw=";
+    hash = "sha256-TgE8JWXXVQxp0aK/vQ6TaSWxHge3X+RpKXjtc2ZkWpM=";
   };
 
   cargoDeps = rustPlatform.importCargoLock {
@@ -31,6 +30,7 @@ python3Packages.buildPythonApplication rec {
     outputHashes = {
       "async_zip-0.0.17" = "sha256-Q5fMDJrQtob54CTII3+SXHeozy5S5s3iLOzntevdGOs=";
       "pubgrub-0.2.1" = "sha256-6tr+HATYSn1A1uVJwmz40S4yLDOJlX8vEokOOtdFG0M=";
+      "reqwest-middleware-0.3.2" = "sha256-OiC8Kg+F2eKy7YNuLtgYPi95DrbxLvsIKrKEeyuzQTo=";
     };
   };
 
@@ -44,7 +44,6 @@ python3Packages.buildPythonApplication rec {
 
   buildInputs = [
     libiconv
-    openssl
   ] ++ lib.optionals stdenv.isDarwin [
     darwin.apple_sdk.frameworks.SystemConfiguration
   ];
@@ -53,10 +52,6 @@ python3Packages.buildPythonApplication rec {
 
   cargoBuildFlags = [ "--package" "uv" ];
 
-  env = {
-    OPENSSL_NO_VENDOR = true;
-  };
-
   postInstall = ''
     export HOME=$TMPDIR
     installShellCompletion --cmd uv \