diff --git a/pkgs/development/python-modules/zope-index/default.nix b/pkgs/development/python-modules/zope-index/default.nix
new file mode 100644
index 000000000000..93c2cf8d90ff
--- /dev/null
+++ b/pkgs/development/python-modules/zope-index/default.nix
@@ -0,0 +1,64 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+
+  # build-system
+  setuptools,
+
+  # dependencies
+  btrees,
+  persistent,
+  zope-interface,
+
+  # tests
+  pytestCheckHook,
+}:
+
+buildPythonPackage rec {
+  pname = "zope-index";
+  version = "8.0";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "zopefoundation";
+    repo = "zope.index";
+    tag = "${version}";
+    hash = "sha256-dHapd/+pJh6qzVx9FGSMmPsGbz8NhAoPqufXm3FOuM8=";
+  };
+
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace-fail "setuptools ==" "setuptools >="
+  '';
+
+  build-system = [
+    setuptools
+  ];
+
+  dependencies = [
+    btrees
+    persistent
+    zope-interface
+  ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+  ];
+
+  pythonImportsCheck = [
+    "zope.index"
+  ];
+
+  pythonNamespaces = [
+    "zope"
+  ];
+
+  meta = {
+    description = "Full-text indexing and searching for Zope";
+    homepage = "https://github.com/zopefoundation/zope.index";
+    changelog = "https://github.com/zopefoundation/zope.index/blob/${version}/CHANGES.rst";
+    license = lib.licenses.zpl21;
+    maintainers = with lib.maintainers; [ daniel-fahey ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 1c5af03f62f4..08b687547a6d 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -20660,6 +20660,8 @@ self: super: with self; {
 
   zope-i18nmessageid = callPackage ../development/python-modules/zope-i18nmessageid { };
 
+  zope-index = callPackage ../development/python-modules/zope-index { };
+
   zope-interface = callPackage ../development/python-modules/zope-interface { };
 
   zope-lifecycleevent = callPackage ../development/python-modules/zope-lifecycleevent { };