diff --git a/pkgs/development/python-modules/pyfuse3/default.nix b/pkgs/development/python-modules/pyfuse3/default.nix
index 588b353078cb..7eeb6ee5601b 100644
--- a/pkgs/development/python-modules/pyfuse3/default.nix
+++ b/pkgs/development/python-modules/pyfuse3/default.nix
@@ -26,6 +26,13 @@ buildPythonPackage rec {
     hash = "sha256-HhEtWYWdxJZOMS3dqB2VdQS7aSdpkRhq7EZCJ55n2OE=";
   };
 
+  patches = [
+    # Fix cross compilation by using PKG_CONFIG env variable instead
+    # of hardcoded binary name
+    # https://github.com/libfuse/pyfuse3/pull/148
+    ./fix_cross_parse_pkg_config.patch
+  ];
+
   build-system = [
     cython
     setuptools
diff --git a/pkgs/development/python-modules/pyfuse3/fix_cross_parse_pkg_config.patch b/pkgs/development/python-modules/pyfuse3/fix_cross_parse_pkg_config.patch
new file mode 100644
index 000000000000..078120de772d
--- /dev/null
+++ b/pkgs/development/python-modules/pyfuse3/fix_cross_parse_pkg_config.patch
@@ -0,0 +1,38 @@
+From a37b18ea421eb20391d0b900844f0c04054247e6 Mon Sep 17 00:00:00 2001
+From: Jonas Heinrich <onny@project-insanity.org>
+Date: Thu, 9 Jul 2026 14:40:16 +0200
+Subject: [PATCH] Fix cross-compilaton by using PKG_CONFIG env variable
+
+---
+ util/build_backend.py | 8 +++++---
+ 1 file changed, 5 insertions(+), 3 deletions(-)
+
+diff --git a/util/build_backend.py b/util/build_backend.py
+index 0ec6b21..95e4ee3 100644
+--- a/util/build_backend.py
++++ b/util/build_backend.py
+@@ -15,11 +15,13 @@
+ def pkg_config(pkg, cflags=True, ldflags=False, min_ver=None):
+     """Frontend to pkg-config"""
+ 
++    PKG_CONFIG = os.environ.get('PKG_CONFIG', 'pkg-config').split()
++
+     if min_ver:
+-        cmd = ['pkg-config', pkg, '--atleast-version', min_ver]
++        cmd = PKG_CONFIG + [pkg, '--atleast-version', min_ver]
+ 
+         if subprocess.call(cmd) != 0:
+-            cmd = ['pkg-config', '--modversion', pkg]
++            cmd = PKG_CONFIG + ['--modversion', pkg]
+             proc = subprocess.Popen(cmd, stdout=subprocess.PIPE)
+             version = proc.communicate()[0].strip()
+             if not version:
+@@ -29,7 +31,7 @@ def pkg_config(pkg, cflags=True, ldflags=False, min_ver=None):
+                     '%s version too old (found: %s, required: %s)' % (pkg, version, min_ver)
+                 )
+ 
+-    cmd = ['pkg-config', pkg]
++    cmd = PKG_CONFIG + [pkg]
+     if cflags:
+         cmd.append('--cflags')
+     if ldflags: