diff --git a/pkgs/development/interpreters/python/hooks/default.nix b/pkgs/development/interpreters/python/hooks/default.nix
index 1a0618225a37..63a2d5fbdd40 100644
--- a/pkgs/development/interpreters/python/hooks/default.nix
+++ b/pkgs/development/interpreters/python/hooks/default.nix
@@ -124,6 +124,15 @@ in rec {
       };
     } ./python-recompile-bytecode-hook.sh ) {};
 
+  pythonRelaxDepsHook = callPackage ({ wheel }:
+    makeSetupHook {
+      name = "python-relax-deps-hook";
+      deps = [ wheel ];
+      substitutions = {
+        inherit pythonInterpreter;
+      };
+    } ./python-relax-deps-hook.sh) {};
+
   pythonRemoveBinBytecodeHook = callPackage ({ }:
     makeSetupHook {
       name = "python-remove-bin-bytecode-hook";
@@ -161,8 +170,8 @@ in rec {
       deps = [ ensureNewerSourcesForZipFilesHook ];
       substitutions = {
         inherit pythonInterpreter;
-    };
-  } ./venv-shell-hook.sh) {});
+      };
+    } ./venv-shell-hook.sh) {});
 
   wheelUnpackHook = callPackage ({ wheel }:
     makeSetupHook {
diff --git a/pkgs/development/interpreters/python/hooks/python-relax-deps-hook.sh b/pkgs/development/interpreters/python/hooks/python-relax-deps-hook.sh
new file mode 100644
index 000000000000..7e1cfe51724b
--- /dev/null
+++ b/pkgs/development/interpreters/python/hooks/python-relax-deps-hook.sh
@@ -0,0 +1,83 @@
+# shellcheck shell=bash
+
+# Setup hook that modifies Python dependencies versions.
+#
+# Example usage in a derivation:
+#
+#   { …, pythonPackages, … }:
+#
+#   pythonPackages.buildPythonPackage {
+#     …
+#     nativeBuildInputs = [ pythonPackages.pythonRelaxDepsHook ];
+#
+#     # This will relax the dependency restrictions
+#     # e.g.: abc>1,<=2 -> abc
+#     pythonRelaxDeps = [ "abc" ];
+#     # This will relax all dependencies restrictions instead
+#     # pythonRelaxDeps = true;
+#     # This will remove the dependency
+#     # e.g.: cde>1,<=2 -> <nothing>
+#     pythonRemoveDeps = [ "cde" ];
+#     # This will remove all dependencies from the project
+#     # pythonRemoveDeps = true;
+#     …
+#   }
+
+_pythonRelaxDeps() {
+    local -r metadata_file="$1"
+
+    if [[ -z "${pythonRelaxDeps:-}" ]] || [[ "$pythonRelaxDeps" == 0 ]]; then
+        return
+    elif [[ "$pythonRelaxDeps" == 1 ]]; then
+        sed -i "$metadata_file" -r \
+            -e 's/(Requires-Dist: \S*) \(.*\)/\1/'
+    else
+        for dep in $pythonRelaxDeps; do
+            sed -i "$metadata_file" -r \
+                -e "s/(Requires-Dist: $dep) \(.*\)/\1/"
+        done
+    fi
+}
+
+_pythonRemoveDeps() {
+    local -r metadata_file="$1"
+
+    if [[ -z "${pythonRemoveDeps:-}" ]] || [[ "$pythonRemoveDeps" == 0 ]]; then
+        return
+    elif [[ "$pythonRemoveDeps" == 1 ]]; then
+        sed -i "$metadata_file" \
+            -e '/Requires-Dist:.*/d'
+    else
+        for dep in $pythonRemoveDeps; do
+            sed -i "$metadata_file" \
+                -e "/Requires-Dist: $dep/d"
+        done
+    fi
+
+}
+
+pythonRelaxDepsHook() {
+    pushd dist
+
+    local -r package="$pname-$version"
+    local -r unpack_dir="unpacked"
+    local -r metadata_file="$unpack_dir/$package/$package.dist-info/METADATA"
+    local -r wheel=$(echo "$package"*".whl")
+
+    @pythonInterpreter@ -m wheel unpack --dest "$unpack_dir" "$wheel"
+    rm -rf "$wheel"
+
+    _pythonRelaxDeps "$metadata_file"
+    _pythonRemoveDeps "$metadata_file"
+
+    if (( "${NIX_DEBUG:-0}" >= 1 )); then
+        echo "pythonRelaxDepsHook: resulting METADATA:"
+        cat "$unpack_dir/$package/$package.dist-info/METADATA"
+    fi
+
+    @pythonInterpreter@ -m wheel pack "$unpack_dir/$package"
+
+    popd
+}
+
+postBuild+=" pythonRelaxDepsHook"
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 2d9631e4ac3b..39f0901a020b 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -119,6 +119,7 @@ in {
     pythonImportsCheckHook
     pythonNamespacesHook
     pythonRecompileBytecodeHook
+    pythonRelaxDepsHook
     pythonRemoveBinBytecodeHook
     pythonRemoveTestsDirHook
     setuptoolsBuildHook