diff --git a/pkgs/development/python-modules/astropy/default.nix b/pkgs/development/python-modules/astropy/default.nix
index 54d41608b31c..c620aacc6bc2 100644
--- a/pkgs/development/python-modules/astropy/default.nix
+++ b/pkgs/development/python-modules/astropy/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   fetchPypi,
-  fetchpatch,
   buildPythonPackage,
   pythonOlder,
 
@@ -63,6 +62,10 @@ buildPythonPackage rec {
     hash = "sha256-OS/utEOyQ3zUwuBkGmXg8VunkeFI6bHl7X3n38s45GA=";
   };
 
+  patches = [
+    ./test_z_at_value_numpyvectorize.patch
+  ];
+
   env = lib.optionalAttrs stdenv.cc.isClang {
     NIX_CFLAGS_COMPILE = "-Wno-error=unused-command-line-argument";
   };
diff --git a/pkgs/development/python-modules/astropy/test_z_at_value_numpyvectorize.patch b/pkgs/development/python-modules/astropy/test_z_at_value_numpyvectorize.patch
new file mode 100644
index 000000000000..5ffa586d06d5
--- /dev/null
+++ b/pkgs/development/python-modules/astropy/test_z_at_value_numpyvectorize.patch
@@ -0,0 +1,33 @@
+From 9a7f821351f0870608b2fa3e1be31bda70707913 Mon Sep 17 00:00:00 2001
+From: "P. L. Lim" <2090236+pllim@users.noreply.github.com>
+Date: Fri, 2 May 2025 13:49:06 -0400
+Subject: [PATCH] TST: xfail test_z_at_value_numpyvectorize for numpy 2.3.dev
+ and later until we can fix the underlying issue
+
+Originally this is
+https://github.com/astropy/astropy/commit/9fce0d46c5e1807d7e1030c3cb0b1a9c0a359dd9
+but the path to the file has changed since the release currently in nixpkgs.
+---
+ astropy/cosmology/_src/tests/funcs/test_funcs.py | 4 ++++
+ 1 file changed, 4 insertions(+)
+
+--- a/astropy/cosmology/funcs/tests/test_funcs.py
++++ b/astropy/cosmology/funcs/tests/test_funcs.py
+@@ -31,6 +31,7 @@
+ )
+ from astropy.cosmology._src.funcs.optimize import _z_at_scalar_value
+ from astropy.units import allclose
++from astropy.utils.compat import NUMPY_LT_2_3
+ from astropy.utils.compat.optional_deps import HAS_SCIPY
+ from astropy.utils.exceptions import AstropyUserWarning
+ 
+@@ -173,6 +174,9 @@ def test_scalar_input_to_output(self):
+ 
+ 
+ @pytest.mark.skipif(not HAS_SCIPY, reason="test requires scipy")
++@pytest.mark.xfail(
++    not NUMPY_LT_2_3, reason="TODO fix: https://github.com/astropy/astropy/issues/18045"
++)
+ def test_z_at_value_numpyvectorize():
+     """Test that numpy vectorize fails on Quantities.
+