diff --git a/pkgs/development/python-modules/pyslim/default.nix b/pkgs/development/python-modules/pyslim/default.nix
new file mode 100644
index 000000000000..fcb53da4a4f3
--- /dev/null
+++ b/pkgs/development/python-modules/pyslim/default.nix
@@ -0,0 +1,45 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+, setuptools-scm
+, pythonOlder
+, msprime
+, numpy
+, tskit
+}:
+
+buildPythonPackage rec {
+  pname = "pyslim";
+  version = "1.0.3";
+  format = "pyproject";
+  disabled = pythonOlder "3.7";
+
+  src = fetchPypi {
+    inherit pname version;
+    hash = "sha256-BRfv5AcdRpnvk7zGeYYWweh+foFEOSZjz3pTjX8KOnA=";
+  };
+
+  nativeBuildInputs = [
+    setuptools-scm
+  ];
+
+  propagatedBuildInputs = [
+    msprime
+    tskit
+    numpy
+  ];
+
+  # Requires non-packaged software SLiM
+  doCheck = false;
+
+  pythonImportsCheck = [
+    "pyslim"
+  ];
+
+  meta = with lib; {
+    description = "Tools for dealing with tree sequences coming to and from SLiM";
+    homepage = "https://github.com/tskit-dev/pyslim";
+    license = licenses.mit;
+    maintainers = with maintainers; [ alxsimon ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index f8239ec37a78..925caade9210 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -9462,6 +9462,8 @@ self: super: with self; {
 
   pysingleton = callPackage ../development/python-modules/pysingleton { };
 
+  pyslim = callPackage ../development/python-modules/pyslim { };
+
   pyslurm = callPackage ../development/python-modules/pyslurm {
     inherit (pkgs) slurm;
   };