diff --git a/pkgs/development/python-modules/astropy/default.nix b/pkgs/development/python-modules/astropy/default.nix
index 4f5586f9aa21..14a80754198b 100644
--- a/pkgs/development/python-modules/astropy/default.nix
+++ b/pkgs/development/python-modules/astropy/default.nix
@@ -1,6 +1,7 @@
 {
   lib,
   fetchPypi,
+  fetchpatch,
   buildPythonPackage,
   pythonOlder,
 
@@ -61,6 +62,12 @@ buildPythonPackage rec {
     inherit pname version;
     hash = "sha256-6S18n+6G6z34cU5d1Bu/nxY9ND4aGD2Vv2vQnkMTyUA=";
   };
+  patches = [
+    (fetchpatch {
+      url = "https://github.com/astropy/astropy/commit/13b89edc9acd6d5f12eea75983084c57cb458130.patch";
+      hash = "sha256-2MgmW4kKBrZnTE1cjYYLOH5hStv5Q6tv4gN4sPSLBpM=";
+    })
+  ];
 
   env = lib.optionalAttrs stdenv.cc.isClang {
     NIX_CFLAGS_COMPILE = "-Wno-error=unused-command-line-argument";
@@ -132,35 +139,21 @@ buildPythonPackage rec {
 
   __darwinAllowLocalNetworking = true;
 
-  # Not running it inside the build directory. See:
-  # https://github.com/astropy/astropy/issues/15316#issuecomment-1722190547
   preCheck = ''
-    cd "$out"
     export HOME="$(mktemp -d)"
     export OMP_NUM_THREADS=$(( $NIX_BUILD_CORES / 4 ))
+    # See https://github.com/astropy/astropy/issues/17649 and see
+    # --hypothesis-profile=ci pytest flag below.
+    cp conftest.py $out/
+    # https://github.com/NixOS/nixpkgs/issues/255262
+    cd "$out"
+  '';
+  pytestFlagsArray = [
+    "--hypothesis-profile=ci"
+  ];
+  postCheck = ''
+    rm conftest.py
   '';
-
-  disabledTests = [
-    # tests for all availability of all optional deps
-    "test_basic_testing_completeness"
-    "test_all_included"
-
-    # May fail due to parallelism, see:
-    # https://github.com/astropy/astropy/issues/15441
-    "TestUnifiedOutputRegistry"
-
-    # flaky
-    "test_timedelta_conversion"
-    # More flaky tests, see: https://github.com/NixOS/nixpkgs/issues/294392
-    "test_sidereal_lon_independent"
-    "test_timedelta_full_precision_arithmetic"
-    "test_datetime_to_timedelta"
-
-    "test_datetime_difference_agrees_with_timedelta_no_hypothesis"
-
-    # SAMPProxyError 1: 'Timeout expired!'
-    "TestStandardProfile.test_main"
-  ] ++ lib.optionals stdenv.hostPlatform.isDarwin [ "test_sidereal_lat_independent" ];
 
   meta = {
     description = "Astronomy/Astrophysics library for Python";