diff --git a/pkgs/development/python-modules/rpy2-robjects/default.nix b/pkgs/development/python-modules/rpy2-robjects/default.nix
new file mode 100644
index 000000000000..566cf7581068
--- /dev/null
+++ b/pkgs/development/python-modules/rpy2-robjects/default.nix
@@ -0,0 +1,63 @@
+{
+  stdenv,
+  lib,
+  buildPythonPackage,
+  fetchurl,
+  fetchpatch2,
+  isPyPy,
+  R,
+  rpy2-rinterface,
+  ipython,
+  jinja2,
+  numpy,
+  pandas,
+  tzlocal,
+  pytestCheckHook,
+}:
+
+buildPythonPackage rec {
+  version = "3.6.2";
+  format = "pyproject";
+  pname = "rpy2-robjects";
+
+  disabled = isPyPy;
+  src = fetchurl {
+    url = "mirror://pypi/${builtins.substring 0 1 pname}/${pname}/${
+      builtins.replaceStrings [ "-" ] [ "_" ] pname
+    }-${version}.tar.gz";
+    hash = "sha256-rJGvMtXE2iNrBaPNaNr7JM2PWogPAHhim48r8CUFQjs=";
+  };
+
+  patches = [
+    # https://github.com/rpy2/rpy2/pull/1171#issuecomment-3263994962
+    (fetchpatch2 {
+      url = "https://github.com/rpy2/rpy2/commit/524546eef9b8f7f3d61aeb76d7e7fa7beeabd2d2.patch?full_index=1";
+      hash = "sha256-aR44E8wIBlD7UpQKm7B+aMn2p3FQ8dwBwLwkibIpcuM=";
+      relative = "rpy2-robjects";
+      revert = true;
+    })
+  ];
+
+  nativeBuildInputs = [
+    R # needed at setup time to detect R_HOME (alternatively set R_HOME explicitly)
+  ];
+
+  propagatedBuildInputs = [
+    ipython
+    jinja2
+    numpy
+    pandas
+    rpy2-rinterface
+    tzlocal
+  ];
+
+  nativeCheckInputs = [ pytestCheckHook ];
+
+  meta = {
+    homepage = "https://rpy2.github.io/";
+    description = "Python interface to R";
+    license = lib.licenses.gpl2Plus;
+    platforms = lib.platforms.unix;
+    maintainers = with lib.maintainers; [ joelmo ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index bcdb188bfe9e..066010586b93 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -16117,6 +16117,8 @@ self: super: with self; {
     inherit (pkgs) zstd;
   };
 
+  rpy2-robjects = callPackage ../development/python-modules/rpy2-robjects { };
+
   rpyc = callPackage ../development/python-modules/rpyc { };
 
   rq = callPackage ../development/python-modules/rq { };