diff --git a/pkgs/applications/science/biology/dssp/default.nix b/pkgs/applications/science/biology/dssp/default.nix
new file mode 100644
index 000000000000..762b0515e85c
--- /dev/null
+++ b/pkgs/applications/science/biology/dssp/default.nix
@@ -0,0 +1,25 @@
+{ lib, stdenv, fetchFromGitHub, boost, cmake, libcifpp, zlib, }:
+
+stdenv.mkDerivation rec {
+  pname = "dssp";
+  version = "4.0.5";
+
+  src = fetchFromGitHub {
+    owner = "PDB-REDO";
+    repo = pname;
+    rev = "v${version}";
+    sha256 = "1x35rdcm4fch66pjbmy73lv0gdb6g9y3v023a66512a6nzsqjsir";
+  };
+
+  nativeBuildInputs = [ cmake ];
+
+  buildInputs = [ boost libcifpp zlib ];
+
+  meta = with lib; {
+    description = "Calculate the most likely secondary structure assignment given the 3D structure of a protein";
+    homepage = "https://github.com/PDB-REDO/dssp";
+    license = licenses.bsd2;
+    maintainers = with maintainers; [ natsukium ];
+    platforms = platforms.unix;
+  };
+}
diff --git a/pkgs/development/libraries/libcifpp/default.nix b/pkgs/development/libraries/libcifpp/default.nix
new file mode 100644
index 000000000000..22c23f45af86
--- /dev/null
+++ b/pkgs/development/libraries/libcifpp/default.nix
@@ -0,0 +1,25 @@
+{ lib, stdenv, fetchFromGitHub, boost, cmake, }:
+
+stdenv.mkDerivation rec {
+  pname = "libcifpp";
+  version = "4.2.0";
+
+  src = fetchFromGitHub {
+    owner = "PDB-REDO";
+    repo = pname;
+    rev = "v${version}";
+    sha256 = "1hzi6fgbsmy8h8nfwkyfds9jz13nqw72h0x81jqw5516kkvar5iw";
+  };
+
+  nativeBuildInputs = [ cmake ];
+
+  buildInputs = [ boost ];
+
+  meta = with lib; {
+    description = "Manipulate mmCIF and PDB files";
+    homepage = "https://github.com/PDB-REDO/libcifpp";
+    license = licenses.bsd2;
+    maintainers = with maintainers; [ natsukium ];
+    platforms = platforms.unix;
+  };
+}
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index e9445d0f3093..61917bf54d4c 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -18729,6 +18729,8 @@ with pkgs;
 
   libchop = callPackage ../development/libraries/libchop { };
 
+  libcifpp = callPackage ../development/libraries/libcifpp { };
+
   libcint = callPackage ../development/libraries/libcint { };
 
   libclc = callPackage ../development/libraries/libclc { };
@@ -33410,6 +33412,8 @@ with pkgs;
 
   diamond = callPackage ../applications/science/biology/diamond { };
 
+  dssp = callPackage ../applications/science/biology/dssp { };
+
   ecopcr = callPackage ../applications/science/biology/ecopcr { };
 
   eggnog-mapper = callPackage ../applications/science/biology/eggnog-mapper { };