diff --git a/pkgs/by-name/si/silx/package.nix b/pkgs/by-name/si/silx/package.nix
new file mode 100644
index 000000000000..3fa944d5ae53
--- /dev/null
+++ b/pkgs/by-name/si/silx/package.nix
@@ -0,0 +1,42 @@
+{
+  python3Packages,
+  fetchPypi,
+  lib,
+}:
+
+python3Packages.buildPythonApplication rec {
+  pname = "silx";
+  version = "2.1.1";
+
+  pyproject = true;
+
+  src = fetchPypi {
+    inherit pname version;
+    hash = "sha256-LfCRWkUrqQb7zxiFTPhy/g9FWhNMXTRbhEgek4tZb5I=";
+  };
+
+  build-system = with python3Packages; [
+    cython
+    setuptools
+  ];
+
+  dependencies = with python3Packages; [
+    h5py
+    numpy
+    matplotlib
+    pyopengl
+    python-dateutil
+    pyside6
+    fabio
+  ];
+
+  meta = {
+    changelog = "https://github.com/silx-kit/silx/blob/main/CHANGELOG.rst";
+    description = "Software to support data assessment, reduction and analysis at synchrotron radiation facilities";
+    homepage = "https://github.com/silx-kit/silx";
+    license = [ lib.licenses.mit ];
+    maintainers = [ lib.maintainers.pmiddend ];
+    mainProgram = "silx";
+  };
+
+}
diff --git a/pkgs/development/python-modules/fabio/default.nix b/pkgs/development/python-modules/fabio/default.nix
new file mode 100644
index 000000000000..8692d8a3c3da
--- /dev/null
+++ b/pkgs/development/python-modules/fabio/default.nix
@@ -0,0 +1,58 @@
+{
+  buildPythonPackage,
+  ninja,
+  fetchPypi,
+  meson,
+  lib,
+  cython,
+  meson-python,
+  numpy,
+  lxml,
+  h5py,
+  hdf5plugin,
+  pillow,
+  tomli,
+}:
+
+buildPythonPackage rec {
+  pname = "fabio";
+  version = "2024.4.0";
+  pyproject = true;
+
+  src = fetchPypi {
+    inherit pname version;
+    hash = "sha256-NPVxu4sZ7hIvrHrh1iRakraa5fj1cUnH259tTDByRNc=";
+  };
+
+  pythonImportsCheck = [ "fabio" ];
+
+  nativeBuildInputs = [
+    meson
+    cython
+    meson-python
+    ninja
+  ];
+
+  # While building, it tries to run version.py, which has a #!/usr/bin/env python3 shebang
+  postPatch = ''
+    patchShebangs --build version.py
+  '';
+
+  dependencies = [
+    numpy
+    lxml
+    h5py
+    hdf5plugin
+    pillow
+    tomli
+  ];
+
+  meta = {
+    changelog = "https://github.com/silx-kit/fabio/blob/main/doc/source/Changelog.rst";
+    description = "I/O library for images produced by 2D X-ray detector";
+    homepage = "https://github.com/silx-kit/fabio";
+    license = [ lib.licenses.mit ];
+    maintainers = [ lib.maintainers.pmiddend ];
+  };
+
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index c5623f6b1344..d18facd85026 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -4360,6 +4360,8 @@ self: super: with self; {
 
   f90nml = callPackage ../development/python-modules/f90nml { };
 
+  fabio = callPackage ../development/python-modules/fabio { };
+
   fabric = callPackage ../development/python-modules/fabric { };
 
   faadelays = callPackage ../development/python-modules/faadelays { };