diff --git a/pkgs/development/interpreters/python/hooks/default.nix b/pkgs/development/interpreters/python/hooks/default.nix
index b4f97d08c693..74aff43f7cae 100644
--- a/pkgs/development/interpreters/python/hooks/default.nix
+++ b/pkgs/development/interpreters/python/hooks/default.nix
@@ -144,9 +144,8 @@ in {
   pythonRelaxDepsHook = callPackage ({ makePythonHook, wheel }:
     makePythonHook {
       name = "python-relax-deps-hook";
-      propagatedBuildInputs = [ wheel ];
       substitutions = {
-        inherit pythonInterpreter;
+        inherit pythonInterpreter pythonSitePackages wheel;
       };
     } ./python-relax-deps-hook.sh) {};
 
diff --git a/pkgs/development/interpreters/python/hooks/python-relax-deps-hook.sh b/pkgs/development/interpreters/python/hooks/python-relax-deps-hook.sh
index 3502fe106369..1ac91fb40e4e 100644
--- a/pkgs/development/interpreters/python/hooks/python-relax-deps-hook.sh
+++ b/pkgs/development/interpreters/python/hooks/python-relax-deps-hook.sh
@@ -84,7 +84,8 @@ pythonRelaxDepsHook() {
 
     # We generally shouldn't have multiple wheel files, but let's be safer here
     for wheel in "$pkg_name"*".whl"; do
-        @pythonInterpreter@ -m wheel unpack --dest "$unpack_dir" "$wheel"
+        PYTHONPATH="@wheel@/@pythonSitePackages@:$PYTHONPATH" \
+            @pythonInterpreter@ -m wheel unpack --dest "$unpack_dir" "$wheel"
         rm -rf "$wheel"
 
         # Using no quotes on purpose since we need to expand the glob from `$metadata_file`
@@ -96,7 +97,8 @@ pythonRelaxDepsHook() {
             cat $metadata_file
         fi
 
-        @pythonInterpreter@ -m wheel pack "$unpack_dir/$pkg_name"*
+        PYTHONPATH="@wheel@/@pythonSitePackages@:$PYTHONPATH" \
+            @pythonInterpreter@ -m wheel pack "$unpack_dir/$pkg_name"*
     done
 
     # Remove the folder since it will otherwise be in the dist output.