diff --git a/pkgs/development/python-modules/devpi-web/default.nix b/pkgs/development/python-modules/devpi-web/default.nix
index e4d7df24bf20..ac54b3525e73 100644
--- a/pkgs/development/python-modules/devpi-web/default.nix
+++ b/pkgs/development/python-modules/devpi-web/default.nix
@@ -1,5 +1,6 @@
 {
   lib,
+  stdenv,
   buildPythonPackage,
   fetchFromGitHub,
   gitUpdater,
@@ -70,6 +71,11 @@ buildPythonPackage (finalAttrs: {
     webtest
   ];
 
+  disabledTests = lib.optionals stdenv.hostPlatform.isDarwin [
+    # https://github.com/devpi/devpi/issues/1114
+    "test_dont_index_deleted_mirror"
+  ];
+
   pythonImportsCheck = [ "devpi_web" ];
 
   # devpi uses a monorepo for server, common, client and web