diff --git a/pkgs/development/python-modules/tskit/default.nix b/pkgs/development/python-modules/tskit/default.nix
new file mode 100644
index 000000000000..bb5139b425b0
--- /dev/null
+++ b/pkgs/development/python-modules/tskit/default.nix
@@ -0,0 +1,46 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+, setuptools-scm
+, pythonOlder
+, numpy
+, jsonschema
+, svgwrite
+}:
+
+buildPythonPackage rec {
+  pname = "tskit";
+  version = "0.5.5";
+  format = "pyproject";
+  disabled = pythonOlder "3.7";
+
+  src = fetchPypi {
+    inherit pname version;
+    hash = "sha256-phhBTAHAPlBnmzSiLmPYDMg1Mui85NZacni3WuYAc6c=";
+  };
+
+  nativeBuildInputs = [
+    setuptools-scm
+  ];
+
+  propagatedBuildInputs = [
+    numpy
+    jsonschema
+    svgwrite
+  ];
+
+  # Pypi does not include test folder and too complex to compile from GitHub source
+  # will ask upstream to include tests in pypi
+  doCheck = false;
+
+  pythonImportsCheck = [
+    "tskit"
+  ];
+
+  meta = with lib; {
+    description = "The tree sequence toolkit";
+    homepage = "https://github.com/tskit-dev/tskit";
+    license = licenses.mit;
+    maintainers = with maintainers; [ alxsimon ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 51955d5577bc..a22eda4290d8 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -12528,6 +12528,8 @@ self: super: with self; {
 
   trytond = callPackage ../development/python-modules/trytond { };
 
+  tskit = callPackage ../development/python-modules/tskit { };
+
   ttach = callPackage ../development/python-modules/ttach { };
 
   ttls = callPackage ../development/python-modules/ttls { };