diff --git a/pkgs/development/libraries/science/biology/htslib/default.nix b/pkgs/development/libraries/science/biology/htslib/default.nix
index 2e3f9dec3194..219c06ce57ad 100644
--- a/pkgs/development/libraries/science/biology/htslib/default.nix
+++ b/pkgs/development/libraries/science/biology/htslib/default.nix
@@ -2,11 +2,11 @@
 
 stdenv.mkDerivation rec {
   pname = "htslib";
-  version = "1.15";
+  version = "1.16";
 
   src = fetchurl {
     url = "https://github.com/samtools/htslib/releases/download/${version}/${pname}-${version}.tar.bz2";
-    sha256 = "sha256-Gp9JkRUDoi9WgXzILqm4f7fnRntf+YnKWqYcEufVMtk=";
+    sha256 = "sha256-YGt8ev9zc0zwM+zRVvQFKfpXkvVFJJUqKJOMoIkNeSQ=";
   };
 
   # perl is only used during the check phase.