diff --git a/pkgs/development/python-modules/synergy/default.nix b/pkgs/development/python-modules/synergy/default.nix
index 8d958862b675..2a60f4b23e5c 100644
--- a/pkgs/development/python-modules/synergy/default.nix
+++ b/pkgs/development/python-modules/synergy/default.nix
@@ -1,31 +1,36 @@
 {
   lib,
+  stdenv,
   buildPythonPackage,
   fetchFromGitHub,
-  pytestCheckHook,
   pythonOlder,
+  setuptools,
   numpy,
   scipy,
   matplotlib,
   plotly,
   pandas,
+  hypothesis,
+  pytestCheckHook,
 }:
 
 buildPythonPackage rec {
   pname = "synergy";
   version = "1.0.0";
-  format = "setuptools";
+  pyproject = true;
+
   disabled = pythonOlder "3.5";
 
-  # Pypi does not contain unit tests
   src = fetchFromGitHub {
     owner = "djwooten";
     repo = "synergy";
     tag = "v${version}";
-    sha256 = "sha256-df5CBEcRx55/rSMc6ygMVrHbbEcnU1ISJheO+WoBSCI=";
+    hash = "sha256-df5CBEcRx55/rSMc6ygMVrHbbEcnU1ISJheO+WoBSCI=";
   };
 
-  propagatedBuildInputs = [
+  build-system = [ setuptools ];
+
+  dependencies = [
     numpy
     scipy
     matplotlib
@@ -33,7 +38,25 @@ buildPythonPackage rec {
     pandas
   ];
 
-  nativeCheckInputs = [ pytestCheckHook ];
+  nativeCheckInputs = [
+    hypothesis
+    pytestCheckHook
+  ];
+
+  disabledTests =
+    [
+      # flaky: hypothesis.errors.FailedHealthCheck
+      "test_asymptotic_limits"
+      "test_inverse"
+      # AssertionError: synthetic_BRAID_reference_1.csv
+      #  E3=0 not in (0.10639582639915163, 1.6900177333904622)
+      "test_BRAID_fit_bootstrap"
+    ]
+    ++ lib.optionals stdenv.hostPlatform.isDarwin [
+      # AssertionError: np.False_ is not true
+      "test_fit_loewe_antagonism"
+    ];
+
   pythonImportsCheck = [ "synergy" ];
 
   meta = with lib; {