diff --git a/pkgs/development/python-modules/anyio/default.nix b/pkgs/development/python-modules/anyio/default.nix
index f5e02b9d2067..2565129d2215 100644
--- a/pkgs/development/python-modules/anyio/default.nix
+++ b/pkgs/development/python-modules/anyio/default.nix
@@ -95,6 +95,8 @@ buildPythonPackage rec {
     "test_nonexistent_main_module"
     #  3 second timeout expired
     "test_keyboardinterrupt_during_test"
+    # racy with high thread count, see https://github.com/NixOS/nixpkgs/issues/448125
+    "test_multiple_threads"
   ]
   ++ lib.optionals stdenv.hostPlatform.isDarwin [
     # PermissionError: [Errno 1] Operation not permitted: '/dev/console'